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ProteomicsRetriever is a multiprotein complex for retromer-independent endosomal cargo recycling
Following endocytosis into the endosomal network, integral membrane proteins undergo sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here we describe the discovery of an ancient and conserved multiprotein complex which orchestrates cargo retrieval and recycl...
ORGANISM(S): Homo sapiens (Human) 
2018-01-15 | PXD007230 | Pride
Snx17 Retriever Retromer 
ProteomicsPhosphorylation of SNX17 impedes activation of Retriever-mediated sorting
Sorting nexin 17 (SNX17) functions as cargo receptor on endosomal membranes that enables the recycling of numerous membrane cargo proteins by binding to the Retriever complex. Yet, little is known how SNX17 activity or its membrane recruitment is regulated. Here, we report that phosphorylation of SN...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-06-30 | PXD061808 | Pride
Endosome Intracellular trafficking Sorting nexin Retriever Phosphorylation Integrin Phox domain 
MetabolomicsNon-targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo
Not available
ORGANISM(S): Canis lupus familiaris 
ST000623 | MetabolomicsWorkbench
ProteomicsIdentification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition
The endosomal-lysosomal network is a hub of organelles that orchestrate the dynamic sorting of hundreds of integral membrane proteins to maintain cellular homeostasis. VPS29 is a central conductor of this network through its assembly into Retromer, Retriever and Commander endosomal sorting complexes...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD064959 | Pride
Commander Retriever Endosomes Lysosomes Retromer 
GenomicsCanis lupus familiaris breed:Labrador retriever
Canis lupus familiaris breed:Labrador retriever Genome sequencing and assembly
PRJNA1531672 | ENA
GenomicsCanis lupus familiaris isolate:SID07034 | breed:Labrador retriever
Canis lupus familiaris isolate:SID07034 | breed:Labrador retriever Genome sequencing and assembly
PRJNA615959 | ENA
GenomicsCanis lupus familiaris breed:Labrador Retriever
2013 TSA Labrador Retriever Cohort
PRJNA832683 | ENA
Genomics
SHAPE3: H. vulgare cultivar Retriever
PRJEB121133 | ENA
UnknownStructural basis for Retriever-SNX17 assembly and endosomal sorting.
Not available
S-EPMC10980035 | biostudies-literature
UnknownMulti-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds.
Not available
S-EPMC8118335 | biostudies-literature
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