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MetabolomicsRetromer mediates Ypt7-dependent lipid droplet internalization

Lipid droplets (LDs) are dynamic organelles central to cellular energy homeostasis and stress adaptation. Maintaining LD balance is critical for cell function, yet the mechanisms governing selective LD degradation remain unclear. Here, we reveal a pathway promoting efficient vacuolar sequestering...

2026-07-15 | MTBLS15038 | MetaboLights
UnknownA luminescent reporter assay to quantify SORL1 ectodomain shedding and retromer-dependent endosome recycling activity.
Not available
S-EPMC12860930 | biostudies-literature
GenomicsThe retromer complex promotes apoptotic cell degradation during efferocytosis
The retromer complex promotes apoptotic cell degradation during efferocytosis
PRJNA1367063 | ENA
ProteomicsSNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion
Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway. Here we demonstrate the essential role of SNX3-ret...
ORGANISM(S): Homo sapiens (Human) 
2018-10-16 | PXD010632 | Pride
Retromer flippase snx3 
ProteomicsEpidermal Stratification Requires Retromer-Mediated Desmoglein-1 Recycling
Sorting transmembrane cargo is essential for tissue development and homeostasis. However, mechanisms of intracellular trafficking in stratified epidermis are poorly understood. Here we identify an interaction between the retromer endosomal trafficking component, VPS35, and the desmosomal cadherin, D...
ORGANISM(S): Homo sapiens (Human) 
2023-07-24 | PXD036646 | Pride
Desmosome  keratinocyte  epidermal differentiation  skin disease  endosomal trafficking  retromer chaperone  vps35  sam syndrome  cadherin  dsg1  glut1  bioid 
GenomicsMultiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health
Multiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health
PRJNA925533 | ENA
ProteomicsIdentification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition
The endosomal-lysosomal network is a hub of organelles that orchestrate the dynamic sorting of hundreds of integral membrane proteins to maintain cellular homeostasis. VPS29 is a central conductor of this network through its assembly into Retromer, Retriever and Commander endosomal sorting complexes...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD064959 | Pride
Commander Retriever Endosomes Lysosomes Retromer 
ProteomicsRetriever is a multiprotein complex for retromer-independent endosomal cargo recycling
Following endocytosis into the endosomal network, integral membrane proteins undergo sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here we describe the discovery of an ancient and conserved multiprotein complex which orchestrates cargo retrieval and recycl...
ORGANISM(S): Homo sapiens (Human) 
2018-01-15 | PXD007230 | Pride
Snx17 Retriever Retromer 
TranscriptomicsThe retromer complex promotes apoptotic cell degradation during efferocytosis
Efficient clearance of dead cells, termed efferocytosis, is essential for maintaining tissue homeostasis. Although the cellular and molecular mechanisms regulating apoptotic cell (AC) internalization are well established, our understanding of AC digestion upon engulfment remains elusive. Here, we sh...
ORGANISM(S): Mus musculus 
2025-11-25 | GSE310776 | GEO
GenomicsEnhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease
Enhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease
PRJNA1113999 | ENA
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