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ProteomicsAPEX2 proximity labeling of PI(3)P dependent ER and early endosome membrane contact tether proteins
To understand the nature of ER and early endosome membrane contact site, we capitalized the MTM1 knock out (KO) HeLa cells that do not dissociate the ER and early endosome membrane contact upon nutrient starvation. By using the Doxycyclin inducible APEX2 fused Rab5A (early endosome marker) expressin...
ORGANISM(S): Homo sapiens (Human) 
2023-01-06 | PXD033846 | Pride
Hela Apex2 Lc-ms Mtm1 Early endosome Er Membrane contact 
GenomicsDownregulation of AATK enhances susceptibility to ferroptosis by promoting endosome recycling in gefitinib-resistant lung cancer cells
Downregulation of AATK enhances susceptibility to ferroptosis by promoting endosome recycling in gefitinib-resistant lung cancer cells
PRJNA1032422 | ENA
ProteomicsAnalysis of signaling endosome composition and dynamics using SILAC in embryonic stem cell-derived neurons
Neurons require efficient transport mechanisms such as fast axonal transport to ensure neuronal homeostasis and survival. Neurotrophins and their receptors are conveyed via fast axonal retrograde transport of signaling endosomes to the soma, where they elicit transcriptional responses. Despite the e...
ORGANISM(S): Mus musculus (Mouse) 
2015-12-21 | PXD002111 | Pride
Mass spectrometry Silac Motor neurons Signalling endosomes 
ProteomicsPDZD8 interacts with Protrudin and Rab7 to form an ER-late endosome membrane contact site that recruits mitochondria
Endosomes regulate a plethora of cellular processes including signaling, nutrient status and organelle quality control by controlling the fate of material entering the cells. Endosomes undergo a process of maturation which specifies whether material will be shuttled back to the cell surface or degra...
ORGANISM(S): Homo sapiens (Human) 
2020-06-02 | PXD015523 | Pride
Human Ls-ms/ms Q exactive plus 
TranscriptomicsDownregulation of AATK enhances susceptibility to ferroptosis by promoting endosome recycling in gefitinib-resistant lung cancer cells
Ferroptosis has been characterised by disruption of the cell membrane through iron-related lipid peroxidation. However, regulation of iron homeostasis in lung cancer cells which are resistant to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) remains unclear. Transcriptome an...
ORGANISM(S): Homo sapiens 
2024-12-13 | GSE246267 | GEO
UnknownHomotypic SCOTIN assemblies form ER-endosome membrane contacts and regulate endosome dynamics.
Not available
S-EPMC10398665 | biostudies-literature
UnknownPI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission.
Not available
S-EPMC8624802 | biostudies-literature
ModelsDel_Conte_Zerial2008_Rab5_Rab7_cut_out_switch
Cut-out switch model Membrane identity and GTPase cascades regulated by toggle and cut-out switches Perla Del Conte-Zerial, Lutz Brusch, Jochen C Rink, Claudio Collinet, Yannis Kalaidzidis, Marino Zerial, and Andreas Deutsch: ...
2024-09-02 | BIOMD0000000174 | BioModels
ProteomicsNicotiana benthamiana endosome LC-MSMS
we performed endosome proteome enrichment assay (Wang et al., 2023). Endosomes were enriched in the 100,000 g (P100) ultracentrifugation fraction from GFP-StKAKU4 transgenic N. benthamiana leaves during P. infestans infection.
ORGANISM(S): Nicotiana Benthamiana 
2025-03-12 | PXD061748 |
UnknownMonoubiquitination of EEA1 regulates endosome fusion and trafficking.
Not available
S-EPMC3673817 | biostudies-literature
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