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ProteomicsQuantitative proteomics of nutrient starved wildtype (WT) and MTM1 knock out (KO) HeLa cells.
Quantitative whole cell proteomics that compare fed or starved wildtype (WT) and MTM1 KO HeLa cells.
ORGANISM(S): Homo sapiens (Human) 
2022-12-22 | PXD033850 | Pride
Lc-ms Starvation Hela Tmt-labeling Mtm1 
GenomicsTamoxifen treatment as a therapeutic approach in a murine model of X-linked myotubular myopathy (Mtm1-/y)
Tamoxifen treatment as a therapeutic approach in a murine model of X-linked myotubular myopathy (Mtm1-/y)
PRJNA671753 | ENA
UnknownModeling the human MTM1 p.R69C mutation in murine Mtm1 results in exon 4 skipping and a less severe myotubular myopathy phenotype.
Not available
S-EPMC3263994 | biostudies-literature
GenomicsGenetic downregulation of Dnm2 as a therapeutic approach in a murine model of X-linked myotubular myopathy (Mtm1-/y)
Genetic downregulation of Dnm2 as a therapeutic approach in a murine model of X-linked myotubular myopathy (Mtm1-/y)
PRJNA671746 | ENA
TranscriptomicsTamoxifen treatment as a therapeutic approach in a murine model of X-linked myotubular myopathy (Mtm1-/y)
In this study, we performed RNA sequencing on tibialis anterior muscle of male mice of 7 weeks of age. WT and Mtm1 deficient (Mtm1-/y) mice as well as tamoxifen-treated WT and tamoxifen-treated Mtm1-/y mice were sequenced.
ORGANISM(S): Mus musculus 
2020-12-15 | GSE160083 | GEO
TranscriptomicsGenetic downregulation of Dnm2 as a therapeutic approach in a murine model of X-linked myotubular myopathy (Mtm1-/y)
In this study, we performed RNA sequencing on tibialis anterior muscle of male mice. WT and Mtm1 deficient (Mtm1-/y) mice as well as on Dnm2+/- mice and on Mtm1-/y mice crossed with Dnm2+/- (Mtm1-/yDnm2+/-) were sequenced. A longitudinal follow up was established by sequencing all the genotypes at E...
ORGANISM(S): Mus musculus 
2020-12-15 | GSE160079 | GEO
GenomicsLoss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy
Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy
PRJNA986481 | ENA
UnknownMTM1 overexpression prevents and reverts BIN1-related centronuclear myopathy.
Not available
S-EPMC10545525 | biostudies-literature
GenomicsGenetic surexpression of human BIN1 as a therapeutic approach in a murine model of X-linked myotubular myopathy (Mtm1-/y)
Genetic surexpression of human BIN1 as a therapeutic approach in a murine model of X-linked myotubular myopathy (Mtm1-/y)
PRJNA671747 | ENA
TranscriptomicsLoss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy
X-linked myotubular myopathy (XLMTM) is a fatal congenital disorder caused by mutations in the MTM1 gene. Currently, there are no approved treatments, though AAV8-mediated gene transfer therapy has shown promise in animal models and preliminarily in patients. However, four patients with XLMTM treate...
ORGANISM(S): Danio rerio 
2023-08-10 | GSE235571 | GEO
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