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Over-expression of Ppz1 is deleterious for yeast cells. Recent studies in our laboratory demonstrated that the over-expression of a catalytically impaired version of Ppz1 (Ppz1R451L) is not toxic, suggesting that the excess of Ppz1 phosphatase activity was responsible for toxicity, possibly due to c...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-10-05 | PXD018100 | Pride
The aim of this study was to investigate the response of human brain endothelial cells to bacterial (group B streptococcus, GBS) infection. Results: GBS WT strain infection results in a specific gene induction pattern that is different from the pilA mutant, but not other mutants such as pilB and srr...
ORGANISM(S): Homo sapiens 
Almost all individuals with Down Syndrome (DS) develop Alzheimer’s disease (AD) by mid to late life. However, the degree to which AD in DS shares pathological changes with sporadic late-onset AD (LOAD) and autosomal dominant AD (ADAD) beyond core AD biomarkers such as amyloid-β (Aβ) and tau is unkno...
ORGANISM(S): Homo sapiens (Human) 
2025-07-08 | PXD064699 | Pride
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