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MetabolomicsMetabolomic determinants of carotid atherosclerosis plaque stability
Our objective is to identify the metabolites associated with stability of carotid atheromatous plaques compared to vulnerable plaques, through a metabolomic approach. Eighty consecutive patients with carotid artery stenosis (CAS) who underwent carotid endarterectomy (CEA) according to current guidel...
2025-06-06 | MTBLS12303 | MetaboLights
TranscriptomicsTranscription profiling of human carotid plaques
This analysis compares gene expression in human carotid plaques with gene expression in major tissues and cell types in the human body (GSE1133, Su et al. 2004). Experiment Overall Design: Human carotid endarterectomies were isolated from six subjects with symptomatic carotid artery disease.
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12828 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling of human carotid atheroma
The aim of this study was to identify new biomarkers and to investigate pathways involved in the progression of human carotid atheroma. The study was conducted from pieces of carotid endarterectomy collected in 32 hypertensive patients. The samples contained media and neo-intima without adventitia. ...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-MTAB-1470 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of asymptomatic and symptomatic atherosclerotic plaques from the same patient
We compared gene expression profiles between asymptomatic and symptomatic atherosclerotic plaques from the same patient. This was accomplished by analyzing carotid plaques from four patients with bilateral high-grade carotid artery stenoses one being symptomatic (TIA or stroke) and the other asympto...
ORGANISM(S): Homo sapiens 
2006-02-10 | E-MEXP-268 | biostudies-arrayexpress
ProteomicsIdentification and label-free quantification of proteins in atherosclerotic human carotid arteries by nanoLC-MS/MS-based shotgun proteomics using data-independent acquisition
We present a proteomics dataset relying on nanoLC-MS/MS-based shotgun proteomics and using data-independent acquisitions on an Orbitrap hybrid instrument to enable comparisons of protein levels in human carotid endarterectomies with atheromatous plaques, complicated lesions, and healthy vasculature....
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056909 | Pride
Atherosclerosis  complicated lesion  human carotid artery  data-independent lc–ms/ms  quantitative label-free proteomics 
TranscriptomicsBiobank of Karolinska Endarterectomy (BiKE)
A biobank collection of carotid plaque samples taken from patients undergoing endarterectomy operations. Samples from carotid plaques and peripheral blood mononuclear cells in a setup with clinical registry data collection. See PMID 22371308 for further details.
ORGANISM(S): Homo sapiens 
2012-03-27 | E-GEOD-21545 | biostudies-arrayexpress
ProteomicsCarotid endarterectomy tissue and tissue-derived extracellular vesicle proteomes from symptomatic and asymptomatic patients
This study sought to compare how the tissue extracellular vesicle proteome of carotid atherosclerotic plaques differs between symptomatic and asymptomatic patients. Carotid arteries samples were collected from symptomatic and asymptomatic patients undergoing endarterectomies. The specimen was grossl...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD052938 | Pride
Atheroslerosis Cardiovascular Carotid Human Extracellular vesicles 
GenomicsRNA expression data from calcified human carotid atherosclerotic plaques
RNA expression data from calcified human carotid atherosclerotic plaques
PRJNA517476 | ENA
ProteomicsIdentification of proteins differentially expressed in atherosclerotic human carotid arteries by label-free proteomics
We present a proteomics dataset that permits the comparison of protein levels in samples obtained from patients by carotid endarterectomies and classified to show complicated lesions and atheromatous plaques, as well in samples from a healthy vasculature. We searched the acquired nanoLC-MS/MS-based ...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD038922 | Pride
Atherosclerosis Complicated lesion Carotid artery Human Data-dependent lc–ms/ms Quantitative label-free proteomics 
GenomicsHomo sapiens
Expression profiles of human carotid plaques
PRJNA111135 | ENA
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