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TranscriptomicsPML regulates PPAR signaling and fatty acid oxidation in breast cancer
Cancer cells exhibit an aberrant metabolism which facilitates more efficient production of biomass, and hence tumor growth and progression. The genetic cues modulating this metabolic switch remain largely undetermined, however. Here we identify a metabolic function for PML which reveals an unexpecte...
ORGANISM(S): Mus musculus 
2013-01-29 | E-GEOD-39220 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq from human prostate cancer-adjacent benign prostatic hyperplasia
Determine a comprehensive transcriptome sequencing profiling of tumor-adjacent (contralateral lobe) benign prostatic hyperplasia, 10X genomics single-cell RNA-sequencing analysis on human surgical specimen.
ORGANISM(S): Homo sapiens 
2025-12-16 | E-MTAB-13764 | biostudies-arrayexpress
TranscriptomicsSubtle variations in Pten dose determine cancer susceptibility: Gene expression profiling of a Ptenhy/+ mouse model
Subtle variations in Pten dose determine cancer susceptibility: Gene expression profiling for MEF cells from a Ptenhy/+ mouse model. We have analyzed the survival and tumor spectrum in a population of Pten ‘hypermorphic’ mice (Ptenhy/+), which express approximately 80% of total Pten protein. Not...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-20316 | biostudies-arrayexpress
TranscriptomicsSystemic elevation of PTEN induces a tumor suppressive metabolic state
Decremental loss of PTEN results in cancer susceptibility and tumor progression. In turn this raises the possibility that PTEN elevation might be an attractive option for cancer prevention and therapy. We have generated several transgenic mouse lines with variably elevated PTEN expression levels, ta...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-35670 | biostudies-arrayexpress
TranscriptomicsSIRT3 opposes metabolic reprogramming of cancer cells through HIF1a destabilization
Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg effect, provides tumor cells with the substrates and redox potential required for the generation of biomass. Here, we show that the mitochondria...
ORGANISM(S): Mus musculus 
2011-03-15 | E-GEOD-27309 | biostudies-arrayexpress
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