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TranscriptomicsTranscription profiling of human multiple myeloma cells ( MM1.S) cells with control or beta-catenin knockdown.
MM1.S cells stably transduced with control or beta-catenin shRNA were established. Total RNA was isolated from 5x 10^6 cells of each in triplicate. Experiment Overall Design: Comparative gene expression profiling in multiple myeloma.
ORGANISM(S): Homo sapiens 
2009-09-15 | E-GEOD-17385 | biostudies-arrayexpress
TranscriptomicsExpression data of lentivirus sponge MicroRNA16 (miR16) downregulated RPMI 8226 and MMS1 multiple myeloma (MM) cell lines compared with control lentivirus sponge
Multiple myeloma is characterized by frequent chromosomal alterations. Deletion of chr 13, especially band 13q14, is commonly observed in early stages of MM, suggesting the presence of tumor suppressor genes (TSG) within this region. We sought to functionally validate the role of the microRNAs-15a/1...
ORGANISM(S): Homo sapiens 
2010-10-20 | E-GEOD-24522 | biostudies-arrayexpress
TranscriptomicsFoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Activated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in the development of cancer. The highly related members of the mammalian FoxO transcription factor family, FoxO1, FoxO3, and FoxO4, represent one of several effector arms of PI3K-AKT signaling, prompting geneti...
ORGANISM(S): Mus musculus 
2011-03-16 | E-GEOD-27932 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human newly diagnised multiple myeloma patients prior to treatment
Samples in this series are pre-treatment bone marrow aspirates from multiple myeloma patients Experiment Overall Design: Samples in this series are: CD-138-selected plasma cells from bone marrow of newly diagnosed multiple myeloma patients susequently treated with Total Therapy
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4452 | biostudies-arrayexpress
TranscriptomicsGenomic Run On (GRO): determination of the nascent transcriptional rates in a spt16 mutant
We analyzed the effect of SPT16 on the transcription rates, mRNA stabilities and mRNA levels by doing GRO experiments in a thermosensitive spt16 point mutant (G132D) mutant at 35 ºC comparing with permisive temperature (30 ºC) and a wt treated in the same way. Cells (wt or spt16 mutant) were grown...
ORGANISM(S): Saccharomyces cerevisiae 
2016-01-05 | E-GEOD-64006 | biostudies-arrayexpress
UnknownColorectal-cancer incidence and mortality with screening flexible sigmoidoscopy.
Not available
S-EPMC3641846 | biostudies-literature
UnknownExtracorporeal Life Support Organization Registry International Report 2022: 100,000 Survivors.
Not available
S-EPMC10962646 | biostudies-literature
UnknownGBA1 rs3115534 Is Associated with REM Sleep Behavior Disorder in Parkinson's Disease in Nigerians.
Not available
S-EPMC12164542 | biostudies-literature
UnknownArthroplasty-CervicalP001 - Double Crush Syndrome of the Vertebral Artery Loop and Foraminal Stenosis Causing Monoparesis
Not available
S-EPMC5724662 | biostudies-literature
UnknownSelf-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients: 5-Year Outcomes of the SURTAVI Randomized Clinical Trial.
Not available
S-EPMC9403849 | biostudies-literature
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