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TranscriptomicsMolecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres
Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disorder characterized by ptosis, dysphagia and proximal limb weakness. Autosomal-dominant OPMD is caused by a short (GCG)8–13 expansions within the first exon of the poly(A)-binding protein nuclear 1 gene (PABPN1), leading to an expanded p...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-26604 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of lymphocytes from patients with B chronic lymphocytic leukemia treated with fludarabine to identify a signature of drug resistance
Identification of a signature of resistance to fludarabine in B chronic lymphocytic leukemia patients in vivo
ORGANISM(S): Homo sapiens 
2009-11-28 | E-MTAB-70 | biostudies-arrayexpress
TranscriptomicsTranscriptome comparison of murine wild-type and dumbo retinas at P15
Hmx1 is a transcription factor expressed in the developing eye and ear and in some other parts of the nervous system. Dumbo mice are carrying the Hmx1 p.Q64X loss-of-function mutation (Munroe et al., 2009. BMC Developmental Biology). Transcriptomic analyses of this mouse model allows to decipher bio...
ORGANISM(S): Mus musculus 
2013-07-24 | E-GEOD-47002 | biostudies-arrayexpress
UnknownQuantum size effect on charges and phonons ultrafast dynamics in atomically controlled nanolayers of topological insulators Bi2Te3.
Not available
S-EPMC5653873 | biostudies-literature
UnknownThe Promise of Personalized TCR-Based Cellular Immunotherapy for Cancer Patients.
Not available
S-EPMC8363295 | biostudies-literature
GenomicsIdentification of building principles of methylation states at CG rich regions by high-throughput editing of a mammalian genome
Methylation is a repressive modification of DNA prevalent throughout mammalian genomes yet mostly absent at CG rich stretches referred to as CGI. Here we identify their building principles by parallel genomic targeting of sequence libraries. Iterative insertions generated over 3,000 variants of gen...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-51170 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte derived dendritic cells treated with DC-SIGN initiates an immature dendritic cell phenotype triggering Rho activation that is utilised by HIV-1
DC-SIGN is a C-type lectin expressed by dendritic cells (DCs) that binds HIV-1, sequestering it within multivesicular bodies to facilitate transmission to CD4+ T cells. Here we characterize the molecular basis of signalling through DC-SIGN by large-scale gene expression profiling and phosphoproteome...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6090 | biostudies-arrayexpress
UnknownTreatment of Swine Closed Head Injury with Perfluorocarbon NVX-428.
Not available
S-EPMC7712073 | biostudies-literature
UnknownFunctional and Structural Characterization of LRRK2 p.V1447L in Parkinson's Disease.
Not available
S-EPMC12553989 | biostudies-literature
MetabolomicsSimilar, but different: structurally related azelaic acid and hexanoic acid trigger differential metabolomic and transcriptomic responses in tobacco cells
BACKGROUND: Plants respond to various stress stimuli by activating an enhanced broad-spectrum defensive ability. The development of novel resistance inducers represents an attractive, alternative crop protection strategy. In this regard, hexanoic acid (Hxa, a chemical elicitor) and azelaic acid (Aza...
2018-10-17 | MTBLS559 | MetaboLights
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