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TranscriptomicsTranscription profiling of striatal samples from 4 CHL2 Q150/Q150 mutant mice and 4 age-matched wild-type mice to investigate the study of huntingtin toxicity and its remedy in model systems.
Achieving a mechanistic understanding of disease and initiating preclinical therapeutic trials necessitate the study of huntingtin toxicity and its remedy in model systems. To allow the engagement of appropriate experimental paradigms, Huntington’s disease (HD) models need to be validated in terms...
ORGANISM(S): Mus musculus 
2008-04-10 | E-GEOD-10202 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatum from 3- and 18-month-old Q92 vs. control animals
Achieving a mechanistic understanding of disease and initiating preclinical therapeutic trials necessitate the study of huntingtin toxicity and its remedy in model systems. To allow the engagement of appropriate experimental paradigms, Huntington’s disease (HD) models need to be validated in terms...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7958 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatum from 12 months-old Hdh4/Q80 mice and control mice.
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transgenic m...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9375 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of striatum from 12 weeks-old R6/2 mice and control mice (set 2)
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transgenic m...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9804 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatum from 12 weeks-old R6/2 mice and control mice (set 1)
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transgenic m...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9803 | biostudies-arrayexpress
TranscriptomicsTranscruption profiling of human cerebellum, frontal cortex [BA4, BA9] and caudate nucleus HD tissue experiment
Post mortem human brain tissue comparison between HD patients and controls from 3 brain regions - cerebellum, frontal cortex [BA4, BA9] and caudate nucleus. Gene expression analysed using linear models from LIMMA package in Bioconductor suite. Experiment Overall Design: Large sample sizes were used...
ORGANISM(S): Homo sapiens 
2009-09-12 | E-GEOD-3790 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatum from 12 weeks-old R6/2 vs. control animals
This SuperSeries is composed of the following subset Series:; GSE9803: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice (set 1); GSE9804: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice (set 2) Experiment Overall Design: Refer to individual Series
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9857 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatal samples from wildtype, Hdh/Q80 animals
This SuperSeries is composed of the following subset Series:; GSE9375: Striatal gene expression data from 12 months-old Hdh4/Q80 mice and control mice. GSE9857: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice; GSE10202: Striatal gene expression data from 22-month-old CHL2 ...
ORGANISM(S): Mus musculus 
2008-05-21 | E-GEOD-10263 | biostudies-arrayexpress
GenomicsNational Cancer Institute (NCI) TARGET: Therapeutically Applicable Research to Generate Effective Treatments

The Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative seeks to accelerate research in novel marker and drug development, along with understanding the molecular basis of pediatric malignancy, through identification of genomic changes associated with the follo...

phs000218.v5.p1 | EGA
TranscriptomicsHost genetic diversity enables experimental Ebola hemorrhagic fever pathogenesis
Zaire ebolavirus (ZEBOV) is among the deadliest known human pathogens, causing severe hemorrhagic fever with high case fatality rates ranging from 70-90%. The lack of effective vaccines or treatment available for ZEBOV renders this pathogen as a significant global biodefense threat, as evidenced by...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-57214 | biostudies-arrayexpress
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