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ProteomicsTapasin assembly surveillance by the RNF185/MBRL ubiquitin ligase complex regulates MHC-I antigen presentation
Immune surveillance by cytotoxic T cells eliminates tumor cells and cells infected by intracellular pathogens. This process relies on the presentation of antigenic peptides on Major Histocompatibility Complex class I (MHC-I) at the cell surface. The loading of these peptides onto MHC-I depends on t...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-09-17 | PXD048728 | Pride
Rnf185 mbrl tapasin 
ProteomicsSuppression of TGF-β/SMAD signaling by an inner nuclear membrane phosphatase complex
Cytokines of the TGF-β superfamily control essential cell fate decisions via receptor regulated SMAD (R-SMAD) transcription factors. Ligand-induced R-SMAD phosphorylation in the cytosol triggers their activation and nuclear accumulation. We determined how R-SMADs are inactivated by dephosphorylation...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD051056 | Pride
Man1 Ctdnep Tgfbeta Smad Nuclear envelope 
ProteomicsThe RNF185/Membralin ubiquitin ligase complex is a new ERAD branch involved in the degradation of a distinct subset of integral membrane proteins.
The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for ubiquitin-mediated quality control of secretory and ER-resident proteins. In the present study, two short-lived ER integral membrane model proteins were used to screen a genome-wide CRISPR-Cas9 library, resulting in t...
ORGANISM(S): Homo sapiens (Human) 
2020-08-03 | PXD018517 | Pride
Endoplasmic reticulum-associated degradation (erad)  e3 ligase rnf185  membralin  tmem259  tmub1  tmub2  ubiquitin 
MetabolomicsSerum Predose Metabolic Profiling For Prediction Of Rosuvastatin Pharmacokinetic Parameters In Healthy Volunteers
Rosuvastatin is a quite known lipid-lowering agent generally used for hypercholesterolemia treatment and coronary artery diseases prevention. There is substantial inter-individual variability in the absorption of statins usually caused by genetic polymorphisms leading to variation in the correspondi...
2021-10-29 | MTBLS3128 | MetaboLights
UnknownDifferences in hormonal levels between heterozygous CYP21A2 pathogenic variant carriers, non-carriers, and females with non-classic congenital hyperplasia.
Not available
S-EPMC9832901 | biostudies-literature
UnknownEvolution during Three Ripening Stages of Evora Cheese.
Not available
S-EPMC7555954 | biostudies-literature
TranscriptomicsPeripheral tissue instruction is the primary determinant of CD8+ T cell pathogenicity: transcription profiling by array of donor CD8+ effector T cells isolated from the secondary lymphoid organs, blood and GVHD-target organs at D+7 post-transplant (FTY720)
This study reports the evolution of the donor CD8 effector T cell transcriptomes at multiple sites and time points within the same host following allo-SCT. Donor derived CD8+ T cells were flow sorted from multiple organs in mice developing GVHD in two clinically relevant murine models of H-2b MHC-ma...
ORGANISM(S): Mus musculus 
2018-03-28 | E-MTAB-5380 | biostudies-arrayexpress
UnknownAcute kidney injury associated to COVID-19 leads to a strong unbalance of circulant immune mediators.
Not available
S-EPMC9309102 | biostudies-literature
UnknownAnalysis of the effectiveness of remote intervention of patients affected by chronic diseases: A systematic review and meta-analysis.
Not available
S-EPMC10540568 | biostudies-literature
TranscriptomicsRedirection of therapeutic T cells to a bone marrow niche improves their persistence and anti-tumor functions: transcription profiling by array of resting memory OT-I T_CXCR4) or OT-I T_Control cells isolated from the spleen 90 days following DC vaccination.
This study reports the improvement in function and antitumor efficacy of CXCR4 overexpression in therapeutic CD8+ T cells. Polyclonal CD8+ T cells from OT-I C57BL/6 (B6) mice were transduced with a modified pMP71 retroviral vector containing murine Cxcr4 and Gfp reporter sequences (T_CXCR4) or with ...
ORGANISM(S): Mus musculus 
2018-03-28 | E-MTAB-6091 | biostudies-arrayexpress
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