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MetabolomicsMild cold exposure mitigates ischemic heart injury through indole-3-acetamide–AHR-mediated SMAD2 proteolysis

Ambient temperature profoundly influences organismal metabolism, physiology, and disease. While cold exposure is a well-recognized risk factor for the onset of myocardial infarction (MI), its impact on the injured heart after MI remains unexplored. Here,&nb...

2026-03-03 | MTBLS13965 | MetaboLights
MetabolomicsSMAD3 and HIF-1α Orchestrate Metabolic Transition to Aerobic Glycolysis as a Critical Prerequisite for Spontaneous Reprogramming of Spermatogonial Stem Cells

Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why addition of epidermal growth factor (EGF), leukemia inhibitory factor (LIF) remarkably enhanced transition efficien...

2025-07-08 | MTBLS12698 | MetaboLights
GenomicsHEB and E2A function as SMAD/FOXH1 cofactors
Nodal signaling, mediated through SMAD transcription factors, is necessary for pluripotency maintenance and endoderm commitment. We have identified a new motif, termed SMAD Complex Associated (SCA) that is bound by SMAD2/3/4 and FOXH1 in human embryonic stem cells (hESCs) and derived endoderm. We de...
ORGANISM(S): Xenopus (Silurana) tropicalis 
2011-08-23 | E-GEOD-30146 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of the SMAD transcription factor family reveals IPO5 as a BMP Receptor-SMAD specific importin
Gene-specific transcription factors (GSTFs) control of gene transcription by DNA binding and specific protein complex recruitment, which regulates promoter accessibility for transcription initiation by RNA polymerase II. GSTFs that are frequently mutated in colon and rectal carcinomas are Suppressor...
ORGANISM(S): Homo sapiens (Human) 
2016-10-10 | PXD004529 | Pride
Transcription regulation Proteomics Smad transcription factor Mass spectrometry Nuclear translocation 
TranscriptomicsOlig1 is a Smad cofactor involved in cell motility induced by transforming growth factor-b
Transforming growth factor (TGF)-β plays crucial roles in embryonic development and adult tissue homeostasis by eliciting various cellular responses in target cells. TGF-β signaling is principally mediated through receptor-activated Smad proteins, which regulate expression of target genes in coope...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46405 | biostudies-arrayexpress
ProteomicsSuppression of TGF-β/SMAD signaling by an inner nuclear membrane phosphatase complex
Cytokines of the TGF-β superfamily control essential cell fate decisions via receptor regulated SMAD (R-SMAD) transcription factors. Ligand-induced R-SMAD phosphorylation in the cytosol triggers their activation and nuclear accumulation. We determined how R-SMADs are inactivated by dephosphorylation...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD051056 | Pride
Man1 Ctdnep Tgfbeta Smad Nuclear envelope 
TranscriptomicsGene expression profiling in murine Smad-deficient CD4+ T cells stimulated with TGF-b
TGF-b is an important pleiotropic cytokine with potent immunoregulatory properties. Although many previous reports have been proposed for the immunoregulatory functions of TGF-b on T cells, such as the suppression of cell proliferation, cytokine production and cytokine signaling, as well as the indu...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-19601 | biostudies-arrayexpress
TranscriptomicsDual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system
This SuperSeries is composed of the following subset Series: GSE40506: Genome-wide mapping of Olig2 targets in primary oligodendrocytes GSE40510: Expression data from Sip1 cKO and control mice spinal cord Refer to individual Series
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-40431 | biostudies-arrayexpress
ProteomicsSMAD nucleocytoplasmic shuttling relies on nucleoporin RanBP2 and VIM-AS1 long non-coding RNA during TGF-β signaling
Activation of the transforming growth factor β (TGF-β) signaling leads to established hallmarks of cancer such as the epithelial-to-mesenchymal transition (EMT), initiating cancer dissemination and increasing chemoresistance. TGF-β signal by binding to its type I and II receptors, leading to paralle...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD057186 | Pride
Cancer  epithelial-to-mesenchymal transition  long non-coding rna  nucleoporin  smad  transforming growth factor β  vim-as1 
GenomicsGenome-wide mapping of Olig2 targets in primary oligodendrocytes
Myelination by oligodendrocytes in the central nervous system (CNS) is essential for proper brain function, yet the molecular determinants that control this process remain poorly understood. The basic helix-loop-helix transcription factors Olig1 and Olig2 promote myelination, whereas bone morphogene...
ORGANISM(S): Rattus norvegicus 
2012-08-31 | E-GEOD-40506 | biostudies-arrayexpress
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