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ProteomicsSmall-molecule inhibitors of CRISPR/Cas13 enable versatile control of RNA knockdown in mammalian cells
Abstract: CRISPR/Cas13 has emerged as a leading platform for carrying out RNA knockdown and editing experiments, and presents an attractive therapeutic alternative to DNA editing technologies. However, strategies to directly modulate its activity in a fast, reliable, and generalizable manner are lac...
ORGANISM(S): Homo sapiens (Human) 
2026-07-17 | PXD063296 | Pride
Crispr/cas13 Cas13 inhibitors Lwacas13a Hdx-ms 
GenomicsTranscriptome changes upon Cas13-based knockdown
Transcriptome changes upon Cas13-based knockdown
PRJNA648763 | ENA
GenomicsMolecular basis of target RNA cleavage by Cas13 I
Molecular basis of target RNA cleavage by Cas13 I
PRJNA1379683 | ENA
GenomicsMolecular basis of target RNA cleavage by Cas13 II
Molecular basis of target RNA cleavage by Cas13 II
PRJNA1379684 | ENA
GenomicsMolecular basis of target RNA cleavage by Cas13 III
Molecular basis of target RNA cleavage by Cas13 III
PRJNA1379689 | ENA
GenomicsIntrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems [Screen]
Intrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems [Screen]
PRJNA837526 | ENA
GenomicsIntrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems [RNA-seq]
Intrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems [RNA-seq]
PRJNA837474 | ENA
GenomicsIntrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems [RIP-seq]
Intrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems [RIP-seq]
PRJNA837609 | ENA
OtherIntrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems [Screen]
CRISPR-Cas13 systems have been adapted as versatile toolkits for RNA-related applications. Here we systematically evaluate the performance of several prominent Cas13 family effectors (Cas13a, Cas13b and Cas13d) under lentiviral vectors and reveal surprisingly differential defects and characteristics...
ORGANISM(S): Homo sapiens synthetic construct 
2023-10-09 | GSE202841 | GEO
TranscriptomicsIntrinsic RNA targeting constrains the utility of CRISPR-Cas13 systems [RNA-seq]
CRISPR-Cas13 systems have been adapted as versatile toolkits for RNA-related applications. Here we systematically evaluate the performance of several prominent Cas13 family effectors (Cas13a, Cas13b and Cas13d) under lentiviral vectors and reveal surprisingly differential defects and characteristics...
ORGANISM(S): Homo sapiens 
2023-10-09 | GSE202838 | GEO
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