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GenomicsLwaCas13a haphazardly targets the human transcriptome
LwaCas13a haphazardly targets the human transcriptome
PRJEB78732 | ENA
TranscriptomicsLwaCas13a haphazardly targets the human transcriptome
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated protein 13a (Cas13a) has been described as a superior tool to short-interfering (si) RNAs for specific gene silencing by targeting RNAs through Watson-Crick binding of the target and activation of nuclease activity. Howeve...
ORGANISM(S): Homo sapiens 
2025-03-17 | E-MTAB-14334 | biostudies-arrayexpress
ProteomicsSmall-molecule inhibitors of CRISPR/Cas13 enable versatile control of RNA knockdown in mammalian cells
Abstract: CRISPR/Cas13 has emerged as a leading platform for carrying out RNA knockdown and editing experiments, and presents an attractive therapeutic alternative to DNA editing technologies. However, strategies to directly modulate its activity in a fast, reliable, and generalizable manner are lac...
ORGANISM(S): Homo sapiens (Human) 
2026-07-17 | PXD063296 | Pride
Crispr/cas13 Cas13 inhibitors Lwacas13a Hdx-ms 
UnknownA Mutated Nme1Cas9 Is a Functional Alternative RNase to Both LwaCas13a and RfxCas13d in the Yeast S. cerevisiae.
Not available
S-EPMC9201564 | biostudies-literature
TranscriptomicsCharacterizing the Collateral Activity of CRISPR/Cas13 in Mammalian Cells: Implications for RNA Editing and Therapeutic Applications
The CRISPR/Cas13 system has garnered attention as a potential tool for RNA editing. However, the degree of collateral activity among various Cas13 orthologs and their cytotoxic effects in mammalian cells remain contentious, potentially impacting their applications. In this study, we observed differe...
ORGANISM(S): Homo sapiens 
2024-01-25 | GSE254168 | GEO
UnknownRNA targeting with CRISPR-Cas13.
Not available
S-EPMC5706658 | biostudies-literature
UnknownTargeting of SPCSV-RNase3 via CRISPR-Cas13 confers resistance against sweet potato virus disease.
Not available
S-EPMC8659606 | biostudies-literature
UnknownLwaCas13a indiscriminately targets the human transcriptome
Not available
ORGANISM(S): Homo sapiens (human) 
S-BSST2016 | biostudies-other
GenomicsHomo sapiens
Characterizing the Collateral Activity of CRISPR/Cas13 in Mammalian Cells: Implications for RNA Editing and Therapeutic Applications
PRJNA1067362 | ENA
UnknownQuantum dot molecular beacons achieve sub-10 pM CRISPR-Cas detection in field-ready assays.
Not available
S-EPMC12313975 | biostudies-literature
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