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ProteomicsONGOING CHROMOSOMAL INSTABILITY ACROSS ANEUPLOID SUBTYPES OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA ASSOCIATES WITH DISEASE PROGRESSION
Chromosomal instability (CIN), defined as an increased occurrence of chromosome segregation errors during cell division, is a prominent form of genomic instability (Bakhoum and Avi Landau, 2017). It is the major cause of aneuploidy, an imbalanced complement of whole chromosomes or chromosome arms, w...
ORGANISM(S): Homo sapiens (Human) 
2023-09-15 | PXD042785 | Pride
Aneuploidy B-cell acute lymphoblastic leukemia Childhood b-all Chromosomal instability 
TranscriptomicsMutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy
Left ventricular noncompaction (LVNC) Causes prominent ventricular trabeculations and reduces cardiac systolic function. The clinical presentation of LVNC ranges from asymptomatic to heart failure. We show that germline mutations in human MIB1 (mindbomb homolog 1), which encodes an E3 ubiquitin liga...
ORGANISM(S): Mus musculus 
2015-08-10 | E-GEOD-71912 | biostudies-arrayexpress
TranscriptomicsChIP-chip by array of mouse embryonic stem cells to analyze Jarid2 binding
Analysis of the binding of Jarid2 in mouse ES cells using a Flag tagged version of Jarid2 and a anti-Flag antibody.
ORGANISM(S): Mus musculus 
2010-04-13 | E-TABM-963 | biostudies-arrayexpress
UnknownLung-resident alveolar macrophages regulate the timing of breast cancer metastasis.
Not available
S-EPMC11568918 | biostudies-literature
ProteomicsTumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis
Development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic colonization and demonstrate that pre-conditioning the brain ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015210 | Pride
Tumour exosomal cemi brain metastasis 
UnknownPregnancy and breastfeeding are associated with less later-life cognitive decline in a longitudinal, prospective cohort.
Not available
S-EPMC12778429 | biostudies-literature
UnknownA circadian checkpoint relocates neutrophils to minimize injury.
Not available
S-EPMC7618653 | biostudies-literature
Proteomics- Identification of Gαi2-interacting proteins via affinity pull-down and quantitative mass-spectrometry analysis.
In studying patients with activating GNAI2 mutations, we observed T cell hyperresponsiveness that was independent of cAMP suppression. Therefore, we hypothesized that Gαi2 utilizes alternative signal transduction pathways which might be delineated by identifying its interacting proteins in T cells. ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2024-09-20 | PXD048980 | Pride
Gpcrs G-protein coupled receptors Gnai2 - gαi2 G-protein 
UnknownHuman RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity.
Not available
S-EPMC10242411 | biostudies-literature
UnknownDietary Intake Regulates the Circulating Inflammatory Monocyte Pool.
Not available
S-EPMC7357241 | biostudies-literature
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