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ProteomicsChemical proteomics discloses petrosapongiolide M, an antiinflammatory marine sesterterpene, as a proteasome inhibitor
Chemical Proteomics based mass spectrometry
ORGANISM(S): Homo sapiens (Human) 
2010-04-29 | PRD000209 | Pride
ProteomicsFatty Acid Synthase as Interacting Anticancer Target of the Terpenoid Myrianthic Acid disclosed by MS-Based Proteomics Approaches
This research focuses on the target deconvolution of the natural compound myrianthic acid, a triterpenoid characterized by an ursane skeleton isolated from the roots of Myrianthus arboreus and from Oenothera maritima Nutt. (Onagraceae), using MS-based chemical proteomic techniques. Application of Dr...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD052306 | Pride
Drug discovery  functional proteomics  fatty acid synthase  t-lip  darts  molecular docking  pre-clinical investigations 
ProteomicsChemical Proteomics Partners identification of Cycloamphilectene
The identification of the cycloamphilectene cellular interactome has been performed, through chemical proteomics, to unambiguously define its mechanism of action and thus to understand its pharmacological effect. To achieve this goal, a small bioactive molecule (cycloamphilectene) linked to a matrix...
ORGANISM(S): Homo sapiens (Human) 
2018-11-26 | PXD000106 | Pride
Mass spectrometry Targets identification Chemical proteomics Natural products 
Proteomicsidentification of the protein targets of a small molecule
Mass spectrometry-based chemical proteomic approaches using limited proteolysis for analysis of the interactions between a small molecule and its protein target(s). DARTS (Drug Affinity Responsive Target Stability) has been used in this study on Hela cell lysate. Ubiquitin carboxyl-terminal hydrolas...
ORGANISM(S): Homo sapiens (Human) 
2024-01-15 | PXD048098 | Pride
Hela cells Orbitrap Lysate Lc-ms/ms 
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