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TranscriptomicsGene expression profiling of miR27a over-expressing RH36 cell lines.
In order to identify direct or indirect miR-27a modulated genes, RH36 cells transfected with miR-27a precursors (pre-miR-27a or pre-control), analyzed 48h post-transfection, were used to perform microarray analysis. Gene expression profiling was carried out in ERMS cell line (RH36) transfected with...
ORGANISM(S): Homo sapiens 
2015-05-04 | E-GEOD-52678 | biostudies-arrayexpress
TranscriptomicsmiR-148b modulates the expression of multiple genes
To identify which miR-148b targets were involved in tumorigenesis, a microarray analysis was performed for miR-148b over-expressing cells versus controls and 129 (49 up and 80 down) modulated genes were revealed. The effects of miR-148b on cancer progression depend on the direct and indirect regulat...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26662 | biostudies-arrayexpress
TranscriptomicsHigh IGFBP2 Expression Correlates with Tumor Severity in Pediatric Rhabdomyosarcoma.
Rhabdomyosarcoma (RMS) is the most common childhood sarcoma and is identified as either the embryonal or alveolar (ARMS) subtype. In approximately 75% of cases, ARMSs are characterized by specific chromosomal translocations that involve PAX and FKHR genes. ARMS gene expression signatures vary, depen...
ORGANISM(S): Homo sapiens 
2011-12-05 | E-GEOD-23196 | biostudies-arrayexpress
TranscriptomicsmiR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS and CSF1
Breast cancer is often fatal during its metastatic dissemination. To unravel the role of microRNAs (miRs) during malignancy, we analyzed miR expression in 77 primary breast carcinomas and identified 16 relapse-associated miRs that correlate with survival and/or distinguish tumor subtypes in differen...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26666 | biostudies-arrayexpress
TranscriptomicsmicroRNA and cancer progression in breast tumors
miRNAs are small non-coding RNAs frequently altered in human malignancies. They regulate protein-coding gene expression by mediating mRNA degradation and/or repressing translation via the association with the 3M-bM-^@M-^Y untranslated region (3M-bM-^@M-^Y UTR) of the mRNAs. Aberrant miRNA expression...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26659 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human peripheral blood lymphocytes cultured in modeled microgravity
In the present study we analyzed miRNA and mRNA expression profiles in human peripheral blood lymphocytes (PBLs) incubated in microgravity condition, simulated by a ground-based Rotating Wall Vessel (RWV) bioreactor. Our results show that 42 miRNAs were differentially expressed in MMG-incubated PBLs...
ORGANISM(S): Homo sapiens 
2014-07-17 | E-GEOD-57408 | biostudies-arrayexpress
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