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MetabolomicsThe pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication

BACKGROUND: In all living organisms, DNA replication is exquisitely regulated in a wide range of growth conditions to achieve timely and accurate genome duplication prior to cell division. Failures in this regulation cause DNA damage with potentially disastrous consequences ...

2022-04-19 | MTBLS4415 | MetaboLights
TranscriptomicsMonopolar attachment of sister kinetochores at meiosis I requires casein kinase 1.
The segregation of maternal centromeres away from the paternal ones during the first division of meiosis depends on the attachment of sister kinetochores to microtubules emanating from the same spindle pole. In budding yeast monopolar attachment requires the recruitment to kinetochores of a protein ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-4792 | biostudies-arrayexpress
GenomicsIdentification of a novel Bromodomain / Casein Kinase II / TAF-containing complex as a regulator of mitotic condensin function
ABSTRACT: Condensin is a central regulator of mitotic genome structure, with mutants showing poorly condensed chromosomes and profound segregation defects. Here we identify the fission yeast NCT complex, comprising the Nrc1 BET-family tandem bromodomain protein (SPAC631.02), Casein Kinase II (CKII) ...
ORGANISM(S): Schizosaccharomyces pombe 
2014-01-10 | E-GEOD-53955 | biostudies-arrayexpress
ProteomicsFACT, PAF-C, and CKII
Protein-protein interaction analysis for RNA Polymerase II and its elongation factors including: the PAF Complex, the FACT Complex, casein kinase II, DSIF, and TFIIF. These studies also characterized a number of casein kinase II phosphorylation sites on the subunits of the PAF Complex.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2015-07-20 | MSV000079197 | MassIVE
ProteomicsData-Independent Acquisition-Based global phosphoproteomics reveals diverse roles of AELs (Arabidopsis EL1-like) Casein kinase 1 in plant development
Casein kinase 1 (CK1) is a highly conserved and ubiquitous serine/threonine protein kinase in eukaryotic cells. AELs (Arabidopsis EL1-like) are plant-specific CK1s and function in a wide range of physiological and signaling processes. To comprehensively understand the cellular functions and regulato...
ORGANISM(S): Arabidopsis Thaliana 
PXD035098 |
Proteomics29RNP kinase - Identification and characterization of chloroplast casein kinase II from Oryza sativa (rice)
We firstly identified a chloroplast casein kinase 2 from rice heparin sepharose enrichmen which could phosphorylate the RNP29. Then we identified the phosphorylation site of RNP29. We also performed the phosophoproteome analysis of rice and compared the phosphorylation site between rice and arabi...
ORGANISM(S): Oryza sativa (Rice) 
2015-04-27 | PXD001168 | Pride
Oryza sativa Chloroplast Casein kinase 2 
ProteomicsDishevelled-3 protein conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1
Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL conformational dynamics under native conditions is unknown. To overcome this limitation, we developed the Fluorescein Arsenical Hairpin Binder- (FlAsH-) based FRET in vivo approach to study DVL conformation in living...
ORGANISM(S): Homo sapiens (Human) 
2019-04-02 | PXD013085 | Pride
Dishevelled Casein kinase 1 ɛ Conformation Phosphorylation Flash-based fret approach 
GenomicsCasein kinase 1 and 2 phosphorylate Argonaute proteins to regulate miRNA-mediated gene silencing
Casein kinase 1 and 2 phosphorylate Argonaute proteins to regulate miRNA-mediated gene silencing
PRJNA999321 | ENA
ProteomicsIdentification of Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1) protein partners using Tandem Affinity Purification and Mass Spectrometry
According to the World Health Organization Report, depressive disorders affect about 10% of the population. The molecular mechanism of the pathogenesis of depression is still not well understood. The new findings point to phosphatases as potential targets for effective depression therapy. The aim of...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-19 | MSV000091093 | MassIVE
ProteomicsCasein kinase 1 and 2 phosphorylate a conserved cluster of Argonaute to control microRNA functionCasein kinase 1 and 2 phosphorylate a conserved cluster of Argonaute to control microRNA function
MicroRNAs (miRNAs) together with Argonaute (AGO) proteins form the core of the RNA-induced silencing complex (RISC) to regulate gene expression of their target RNAs post-transcriptionally. Argonaute proteins are subjected to intensive regulation via various post-translational modifications that can ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD043913 | Pride
Argonaute/ck1a1/ck2/microrna/phosphorylation 
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