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ProteomicsThe nitrobenzoxadiazole derivative NBDHEX behaves as Plasmodium falciparum gametocyte selective inhibitor with malaria parasite transmission blocking activity
This work describes the activity of 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX) and of its newly identified carboxylic acid metabolite on human malaria parasite Plasmodium falciparum. NBDHEX has been previously identified as a potent cytotoxic agent against murine and human can...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2022-03-03 | PXD030336 | Pride
Malaria  plasmodium falciparum transmission  nbdhex  mass spectrometry 
ProteomicsProteomic signature of plasma-derived exosomes in different stages of melanoma patients.
Exosomes, extracellular vesicles of 30-150 nm, are released by normal and tumor cells. These nanovesicles play a major role in cell communication and can be found in biological fluids as carriers of biomarkers. Tumor exosomes can inhibit immune responses, mediate drug resistance and transform mesenc...
ORGANISM(S): Homo sapiens (Human) 
2023-05-09 | PXD024434 | Pride
Exosomes Proteomics Melanoma 
ProteomicsSpastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation
Hereditary Spastic Paraplegia (HSP) is a neurodegenerative disease most commonly caused by autosomal dominant mutations in the SPG4 gene encoding the microtubule severing protein spastin. We hypothesise that SPG4-HSP is attributable to reduced spastin function due to haploinsufficiency, thus therape...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2020-10-22 | PXD021945 | Pride
Ubiquitination Spastin Hipk2 Spg4-hsp Protesomal degradation 
ProteomicsProteomic profile of extracellular vesicles from plasma and CSF of multiple sclerosis patients reveals disease activity-associated EAAT2
Multiple Sclerosis (MS) is the most common disabling neurologic disease of young people. The pathological course of MS is heterogeneous in clinical manifestations, response to therapies and outcome, in addition to distinctive clinical courses. For relapsing remitting multiple sclerosis (RRMS) there...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-27 | MSV000092276 | MassIVE
ProteomicsEnhancing the efficacy in melanoma treatment: the chemosensitising role of Vipera ammodytes venom on human melanoma cell lines.
This study investigates the potential of Vipera ammodytes venom as a therapeutic agent for human melanoma, specifically evaluating its cytotoxicity and chemosensitizing effects. Proteomic analysis identified over 125 proteins in the venom, with phospholipases A2, C type lectins, and metalloproteinas...
ORGANISM(S): Vipera Ammodytes Ammodytes (ncbitaxon:8705) 
2025-01-13 | MSV000096836 | MassIVE
ProteomicsDietary relevant concentrations of BDE-47, -99, -209 and their mixture differently affect HepG2 transcriptomic and proteomic profiles.
Polybrominated diphenyl ethers (PBDEs) are man made chemicals with flame retardant properties which are added to commercial products and materials such as textiles, plastics, electronic devices, household products and furniture to reduce their flammability. In the present study we investigated the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-14 | MSV000088230 | MassIVE
ProteomicsChlorpyrifos induces autophagy in murine GnRH neurons by repressing the mTOR pathway and affecting androgen and estrogen alpha/beta receptor expression
Chlorpyrifos (CPF) is a widely used pesticide inducing neurodevelopmental and reproductive adverse effects. Little is known about the underlying mechanisms, especially in hypothalamus. We investigated CPF mode of action at human relevant concentrations (1 nM_100 nM) in immortalized murine hypothalam...
ORGANISM(S): Mus Musculus 
2023-10-05 | MSV000093047 | MassIVE
ProteomicsHoney bee arginine kinase is involved in Deformed Wing Virus infection
Deformed wing virus (DWV) is a major bee pathogen that is actively transmitted by the parasitic mite Varroa destructor and plays a primary role in overwinter colony losses of Apis mellifera. Despite of the intense investigation driven by the unique environmental and economic importance of this essen...
ORGANISM(S): Varroa Destructor (ncbitaxon:109461) Apis Mellifera (ncbitaxon:7460) 
2024-02-20 | MSV000094125 | MassIVE
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