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GenomicsCaspase-10 affects PBC pathogenesis
Caspase-10 affects PBC pathogenesis
PRJNA863615 | ENA
ProteomicsA high-throughput screening approach identified a selective pro-caspase-10 probe that can inhibit its activity
Caspases are cysteine proteases that play a critical role in inflammation and apoptosis. Caspases have a functional role in either the intrinsic apoptotic pathway as initiators of apoptosis or in the extrinsic apoptotic pathway as executioners of apoptosis. Caspase-10 has been speculated to play a p...
ORGANISM(S): Homo sapiens (Human) 
2025-02-04 | PXD053315 | Pride
Caspase-10 Hts Biotin azide 
ProteomicsA high-throughput screening approach identified a selective pro-caspase-10 probe that can inhibit its activity
Caspases are cysteine proteases that play a critical role in inflammation and apoptosis. Caspases have a functional role in either the intrinsic apoptotic pathway as initiators of apoptosis or in the extrinsic apoptotic pathway as executioners of apoptosis. Caspase-10 has been speculated to play a p...
ORGANISM(S): Homo sapiens (Human) 
2025-02-04 | PXD051710 | Pride
Caspase-10 Hts Isotop-abpp 
TranscriptomicsCaspase-10 is a negative regulator of caspase-8-mediated cell death with gene inductive properties
Formation of the Death-Inducing Signalling Complex (DISC) initiates the extrinsic apoptotic signalling cascade. Caspase-8 and its regulator cFLIP control death signalling by binding to the receptor via DISC-bound FADD. By elucidating the function of Caspase-10, a close homologue of caspase-8, we une...
ORGANISM(S): Homo sapiens 
2016-04-20 | GSE75365 | GEO
TranscriptomicsCaspase-10 affects PBC pathogenesis
The loss of functional caspase-10 promotes inflammatory cell death in macrophages and a fibrotic response of hepatic stellate cells, which may affect the pathogenesis of PBC.
ORGANISM(S): Homo sapiens 
2022-12-31 | GSE210070 | GEO
TranscriptomicsControl of Autophagic Cell Death by Caspase-10 in Multiple Myeloma
We performed a loss-of-function, RNA interference screen to define new therapeutic targets in multiple myeloma, a genetically diverse plasma cell malignancy. Unexpectedly, we discovered that all myeloma lines require caspase-10 for survival, irrespective of their genetic abnormalities. The transcrip...
ORGANISM(S): Homo sapiens 
2013-03-13 | E-GEOD-43878 | biostudies-arrayexpress
TranscriptomicsControl of Autophagic Cell Death by Caspase-10 in Multiple Myeloma
We performed a loss-of-function, RNA interference screen to define new therapeutic targets in multiple myeloma, a genetically diverse plasma cell malignancy. Unexpectedly, we discovered that all myeloma lines require caspase-10 for survival, irrespective of their genetic abnormalities. The transcrip...
ORGANISM(S): Homo sapiens 
2013-03-13 | GSE43878 | GEO
UnknownCaspase-10 is an initiator caspase in death receptor signaling.
Not available
S-EPMC61136 | biostudies-literature
GenomicsHomo sapiens
Caspase-10 is a negative regulator of caspase-8-mediated cell death with gene inductive properties
PRJNA304012 | ENA
UnknownAn activation-based high throughput screen identifies caspase-10 inhibitors.
Not available
S-EPMC11854450 | biostudies-literature
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