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ProteomicsBiomarkers of pediatric cataracts: a proteomics analysis of aqueous fluid
Abstract Background: Cataracts are among the most common causes of childhood vision loss worldwide. This study seeks to identify differentially expressed proteins in the aqueous humor of pediatric cataract patients. Methods: Samples of aqueous humor were collected from pediatric and adult cataract...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD022529 | Pride
Q-exactive Pediatric cataracts  proteomics  aqueous humor Lfq 
ProteomicsProteomics analyses of small extracellular vesicles of aqueous humor: identification and validation of GAS6 and SPP1 as glaucoma markers during cataracts surgery
A high percentage of vision loss and blindness worldwide are due to glaucoma and cataracts ocular diseases. Small extracellular vesicles (sEVs) are small lipidic vesicles involved in transport and cell-to-cell communication, released into different body fluids including eye’s aqueous humor. The iden...
ORGANISM(S): Homo sapiens (Human) 
2024-11-04 | PXD048815 | Pride
Glaucoma diagnosis Proteomics Aqueous humor Glaucoma Small extracellular vesicles Elisa Cataracts 
TranscriptomicsGenome-wide analysis of Tdrd7 knockdown in lens epithelial-derived cell line 21EM15
Analysis of Tdrd7 deficiency in mouse lens epithelial-derived cell line at gene expression level. The hypothesis tested was that Tdrd7 is involved in post-transcriptional control of gene expression in the lens. Results provide evidence for differential regulation of genes involved in lens homeostasi...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-25774 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of 4-day old (P4) Tdrd7 null mouse lens
Analysis of Tdrd7 deficiency in mouse lens epithelial-derived cell line at gene expression level. The hypothesis tested was that Tdrd7 is involved in post-transcriptional control of gene expression in the lens. Results provide evidence for differential regulation of genes involved in lens homeostasi...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-25775 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of 1 month old (P30) Tdrd7 null mouse lens
Analysis of Tdrd7 deficiency in mouse lens epithelial-derived cell line at gene expression level. The hypothesis tested was that Tdrd7 is involved in post-transcriptional control of gene expression in the lens. Results provide evidence for differential regulation of genes involved in lens homeostasi...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-25776 | biostudies-arrayexpress
ProteomicsProtein expression in heated rat lens using shotgun proteomics
Previous studies have reported that a strong correlation between the estimated cumulative thermal exposure in the crystalline lens and the incidence of nuclear cataracts; however, the precise relationship between temperature and cataracts remains to be fully elucidated. In the present study, the sho...
ORGANISM(S): Rattus 
2024-09-22 | PXD056067 | JPOST Repository
ProteomicsLens Disulfide crosslink
Low glutathione levels are associated with crystallin oxidation in age-related nuclear cataract (ARNC). To understand the role of cysteine residue oxidation, we used the novel approach of comparing human cataracts with glutathione-depleted LEGSKO mouse lenses for intra- vs. intermolecular disulfide ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-07-20 | MSV000079952 | MassIVE
TranscriptomicsRNA-seq of human lens with cataracts, alopecia, & microdontia
The genetic daignosis of a pediatric patient with primary symptoms bilateral cataracts, alopecia and microdontia could not be obtained through standard genetic tests. We sought to obtain the diagnosis of this rare syndrome through RNA-seq of the cataract lens against an age-matched donor lens.
ORGANISM(S): Homo sapiens 
2021-12-12 | GSE124121 | GEO
GenomicsA transcriptomic analysis of diploid and triploid Atlantic salmon lenses with and without cataracts
A transcriptomic analysis of diploid and triploid Atlantic salmon lenses with and without cataracts
PRJNA644578 | ENA
TranscriptomicsA transcriptomic analysis of diploid and triploid Atlantic salmon lenses with and without cataracts
To avoid negative environmental impacts of escapees and potential inter-breeding with wild populations, the Atlantic salmon farming industry has and continues to extensively test triploid fish that are sterile. However, they often show differences in performance, physiology, behavior and morphology ...
ORGANISM(S): Salmo salar 
2020-07-08 | GSE153933 | GEO
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