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ProteomicsT-type calcium channel inhibitors induce apoptosis in medulloblastoma cells associated with altered metabolic activity
Medulloblastoma (MB) is the most common malignant paediatric brain tumour. In our previous studies, we developed a novel 3D assay for MB cells and screened of plasma membrane calcium channel modulators. These studies identified T-type (CaV3) channel inhibitors, mibefradil and NNC-55-0396 (NNC) as se...
ORGANISM(S): Homo sapiens (Human) 
2023-04-27 | PXD026988 | Pride
Proteomics Medulloblastoma Cav3 inhibitors Calcium channels Apoptosis Therapy 
ProteomicsCardioprotection by selective SGLT2 inhibitors in a non-diabetic mouse model of myocardial ischemia/reperfusion injury: a class or a drug effect?
Major clinical trials with sodium glucose co-transporter-2 inhibitors (SGLT-2i) exhibit protective effects against heart failure events, whereas inconsistencies regarding the cardiovascular death outcomes are observed. Therefore, we aimed to compare the selective SGLT-2i empagliflozin (EMPA), dapagl...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-17 | MSV000088582 | MassIVE
UnknownT-Type Calcium Channel Inhibitors Induce Apoptosis in Medulloblastoma Cells Associated with Altered Metabolic Activity.
Not available
S-EPMC9016057 | biostudies-literature
UnknownMEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy.
Not available
S-EPMC10110893 | biostudies-literature
UnknownThe Tarantula Toxin ω-Avsp1a Specifically Inhibits Human CaV3.1 and CaV3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor.
Not available
S-EPMC9138389 | biostudies-literature
UnknownStructure-Function Studies of Sponge-Derived Compounds on the Cardiac CaV3.1 Channel.
Not available
S-EPMC9962600 | biostudies-literature
UnknownCyclic Peptides as T-Type Calcium Channel Blockers: Characterization and Molecular Mapping of the Binding Site.
Not available
S-EPMC8369677 | biostudies-literature
UnknownSimilar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle.
Not available
S-EPMC5444588 | biostudies-literature
UnknownCa-α1T, a fly T-type Ca2+ channel, negatively modulates sleep.
Not available
S-EPMC4673464 | biostudies-literature
UnknownGlucocorticoids preserve the t-tubular system in ventricular cardiomyocytes by upregulation of autophagic flux.
Not available
S-EPMC9380897 | biostudies-literature
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