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ProteomicsA20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-kB signaling in activated T cells
T cell activation initiates protective adaptive immunity, but counterbalancing mechanisms are critical to prevent overshooting responses and to maintain immune homeostasis. The CARD11-BCL10-MALT1 (CBM) complex bridges T cell receptor engagement to canonical NF-B signaling and MALT1 protease activati...
ORGANISM(S): Homo sapiens (Human) 
2022-01-30 | PXD028680 | Pride
Adaptive immunity A20 T cell signaling Immune suppression Proteomics Abin1 Mass spectrometry Ip-ms Cbm complex 
UnknownLUBAC modulates CBM complex functions downstream of TRAF6 in T cells.
Not available
S-EPMC12602705 | biostudies-literature
UnknownThe CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.
Not available
S-EPMC4167767 | biostudies-literature
UnknownA20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.
Not available
S-EPMC8803816 | biostudies-literature
UnknownCARD9 Forms an Alternative CBM Complex in Richter Syndrome.
Not available
S-EPMC8833648 | biostudies-literature
UnknownThe CBM signalosome: potential therapeutic target for aggressive lymphoma?
Not available
S-EPMC4080217 | biostudies-literature
UnknownTargeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy.
Not available
S-EPMC6656391 | biostudies-literature
UnknownOverexpression, crystallization and preliminary X-ray characterization of Ruminococcus flavefaciens scaffoldin C cohesin in complex with a dockerin from an uncharacterized CBM-containing protein.
Not available
S-EPMC4118804 | biostudies-literature
TranscriptomicsTargeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma (Affy SNP6.0 Arrays)
Chronic active B cell receptor (BCR) signaling, a hallmark of the ABC subtype of diffuse large B cell lymphoma (DLBCL), engages the CARD11-MALT1-BCL10 (CBM) adapter complex to activates IkappaB kinase (IKK) and the classical NF-kappaB pathway. Here we show that the CBM complex includes the E3 ubiqui...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-73639 | biostudies-arrayexpress
TranscriptomicsTargeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma (Agilent Arrays)
Chronic active B cell receptor (BCR) signaling, a hallmark of the ABC subtype of diffuse large B cell lymphoma (DLBCL), engages the CARD11-MALT1-BCL10 (CBM) adapter complex to activates IkappaB kinase (IKK) and the classical NF-kappaB pathway. Here we show that the CBM complex includes the E3 ubiqui...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-73281 | biostudies-arrayexpress
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