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MetabolomicsA gut microbiota–20-HETE lipid signaling axis drives neuroinflammation and anxiety after TBI

A gut microbiota–20-HETE lipid signaling axis drives neuroinflammation and anxiety after TBI


Probiotic L. reuteri attenuates neuroinflammation and anxiety symptoms through gut-brain axis via a novel metabolite 20-HETE in blast-induced traumatic brain injury

2026-07-17 | MTBLS15072 | MetaboLights
TranscriptomicsA20 IN MARGINAL ZONE LYMPHOMAS
Unique and shared cytogenetic abnormalities have been documented for marginal zone lymphomas (MZLs) arising at different sites. Recently, homozygous deletions of the chromosomal band 6q23, involving the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) gene, a negative regulator of NF-kap...
ORGANISM(S): Homo sapiens 
2009-04-01 | E-GEOD-13989 | biostudies-arrayexpress
MetabolomicsX-ray Irradiation Suppresses Keloid Growth by Inducing G2/M Arrest via the Phytosphingosine-KIF20A Axis
Keloid radiotherapy is clinically effective but has an incomplete underlying molecular mechanism and limited accessibility; we used X-ray exposure to identify effector pathways replicating its antifibrotic benefits without further radiation. After collecting patient keloid samples, primary human kel...
2026-06-06 | MTBLS14461 | MetaboLights
ProteomicsMouse WT vs. A20 KO BMDM differential proteomics
A20 is a negative regulator of NF-κB signaling, crucial to control inflammatory responses and ensure tissue homeostasis. A20 is thought to restrict NF-κB activation both by its ubiquitin-editing activity as by non-enzymatic activities. Besides its role in NF-κB signaling, A20 also acts as a protecti...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-15 | PXD008726 | Pride
A20 Lc-msms Bmdm 
GenomicsSaccharolobus sp. A20
Saccharolobus sp. A20 Genome sequencing and assembly
PRJNA339201 | ENA
TranscriptomicsTNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
Classical Hodgkin lymphoma (cHL) is one of the most common malignant lymphomas. It is characterized by the presence of rare Hodgkin and Reed/Sternberg (HRS) cells embedded in an extensive inflammatory infiltrate. Constitutive activation of nuclear factor-kappaB (NF-kappaB) in HRS cells which transcr...
ORGANISM(S): Homo sapiens 
2010-05-20 | E-GEOD-15264 | biostudies-arrayexpress
TranscriptomicsA20 Role in Liver regeneration
Genome wide transcriptional profiling on liver mRNA retrieved from recombinant adenovirus A20 (rAd.A20) and rAd.bgalactosidase transduced livers, before and 24 hours after 78% extended liver resection. Overexpression of the NF-kB inhibitory protein A20 improves recovery of liver function and mass fo...
ORGANISM(S): Mus musculus 
2010-09-18 | E-GEOD-24203 | biostudies-arrayexpress
GenomicsEscherichia coli strain:A20
Escherichia coli strain:A20 Genome sequencing and assembly
PRJNA716053 | ENA
GenomicsStreptococcus pyogenes A20
Streptococcus pyogenes A20 Genome sequencing
PRJNA175952 | ENA
TranscriptomicsTranscription profiling of mouse B lymphoma derived A20 cells - effects of JNK on TGF-beta responses of
TGF-beta plays multiple functions in a board range of cellular responses such as proliferation, differentiation, motility and survival by activating several cellular signaling pathways, including Smads and MAP kinases (Erk, JNK and p38). In particular, TGF-beta can activate pro- or anti-apoptotic si...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7503 | biostudies-arrayexpress
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