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ProteomicsThe HDAC inhibitor SAHA regulates CBX2 stability via a SUMO-triggered ubiquitin-mediated pathway in leukemia
Leukemias are characterized by bone marrow failure due to oncogenic mutations of hematopoietic stem cells (HSC) or blood precursor cells. HSC differentiation and self-renewal properties are tightly regulated by Polycomb group (PcG) proteins, a well-characterized family of transcriptional epigenetic ...
ORGANISM(S): Homo sapiens (Human) 
2018-02-27 | PXD008287 | Pride
Saha Sumoylation Leukemia Cbx2 
GenomicsControl of hematopoiesis by Cbx2
Control of hematopoiesis by Cbx2
PRJNA742429 | ENA
GenomicsCBX2 knockdown in the PEO1 high grade serous cell line
CBX2 knockdown in the PEO1 high grade serous cell line
PRJNA1055963 | ENA
GenomicsCBX2 overexpression in the OVCAR4 high grade serous cell line
CBX2 overexpression in the OVCAR4 high grade serous cell line
PRJNA1055964 | ENA
GenomicsCBX2 Knockout in the OVCAR4 high grade serous cell line
CBX2 Knockout in the OVCAR4 high grade serous cell line
PRJNA1055962 | ENA
GenomicsThe molecular role of CBX2 in acute myeloid leukemia (AML)
The molecular role of CBX2 in acute myeloid leukemia (AML)
PRJNA796331 | ENA
GenomicsH3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [Cbx2_ChIP]
The goal of this study is to understand the genome-wide alterations in chromatin landscape induced by a histone mutation (H3.3K36M) derived from chondroblastomas Examination of genome-wide Cbx2 distribution in cells expressing H3.3WT and H3.3K36M.
ORGANISM(S): Mus musculus 
2016-05-13 | E-GEOD-75856 | biostudies-arrayexpress
TranscriptomicsExpression data from Mouse embryo
Mice lacking the function of the PcG protein CBX2 (also known as M33) show defects in gonadal, adrenal, and splenic development. In particular, XY knockout mice develop ovaries but not testes, and the gonads are hypoplastic in both sexes. To clarify the molecular basis of the defects, RNA prepared f...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-29485 | biostudies-arrayexpress
GenomicsLoss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements
Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements
PRJNA657852 | ENA
GenomicsThe effect of CBX2 knockdown on gene expression in MCF-7 cells
The effect of CBX2 knockdown on gene expression in MCF-7 cells
PRJNA815062 | ENA
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