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TranscriptomicsU937 scramble vs shHDAC2 upon SAHA (Vorinostat; suberoylanilide hydroxamic acid) treatment
Transcriptional profiling of U937 scramble vs shHDAC2 before and after SAHA treatment at 5µM concentration for 6 and 24 hours. Different Experimental Conditions: U937 scramble (U937 trasfected with empty vector) vs shHDAC2 (U937 trasfected with shHDAC2 vector), untreated and treated with SAHA at 5 ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-37529 | biostudies-arrayexpress
TranscriptomicsExpression data from SKOV3 cells treated with SAHA or vehicle control
We performed a microarray experiment to assess SAHA-induced changes in expression of genes of the homologous recombination DNA repair pathway SKOV-3 ovarian cancer cells were treated with 1µM SAHA or vehicle-control (0.01% DMSO) for 6 or 24 hours, harvested and processed for RNA isolation. Data fo...
ORGANISM(S): Homo sapiens 
2014-03-19 | E-GEOD-53603 | biostudies-arrayexpress
TranscriptomicsRNA expression in MDA-MB-231 cells treated for 24h with SAHA, Pargyline, or both [HG-U133A_2]
Abnormal activities of histone lysine demethylases (KDMs) and lysine deacetylases (HDACs) are associated with aberrant gene expression in breast cancer development. However, the precise molecular mechanisms underlying the crosstalk between KDMs and HDACs in chromatin remodeling and regulation of gen...
ORGANISM(S): Homo sapiens 
2015-09-04 | E-GEOD-72688 | biostudies-arrayexpress
ProteomicsAn integrated systems biology approach reveals positive and negative effects of suberoylanilide hydroxamic acid (SAHA) on HIV reactivation from latency
Suberoylanilide hydroxamic acid (SAHA) has been assessed in clinical trials as part of a “shock and kill” strategy to cure HIV-infected patients. While it was effective at inducing expression of HIV RNA "shock" , treatment with SAHA did not result in the reduction of reservoir size "kill". We theref...
ORGANISM(S): Homo sapiens (Human) 
2015-09-10 | PXD002150 | Pride
Human Hiv latency Cd4 t-cells Saha Suberoylanilide hydroxamic acid 
TranscriptomicsExpression data from human hepatic stellate cell line LX2 treated with suberoylanilide hydroxamic acid (SAHA) or valproic acid (VPA)
Suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) are both histone deacetylases inhibitor (HDACi), and are able to attenuate the activation of hepatic stelllate cells. To explore the underlying molecular mechanisms, we performed gene expression profile analyses of human hepatic stellate...
ORGANISM(S): Homo sapiens 
2016-04-07 | E-MTAB-3764 | biostudies-arrayexpress
TranscriptomicsGlobal mRNA expression profiling of murine primary PDAC cells following JQ1 or SAHA monotherapy as well as JQ1-SAHA combination therapy
Global mRNA expression profiles of murine primary PDAC cells following JQ1 or SAHA monotherapy as well as JQ1-SAHA combination therapy were collected using Affymetix mouse whole genome array (Mouse Genome 430A 2.0 Array) . Primary PDAC cells isolated from Ptf1aCre/+;Kras+/LSL-G12D;p53lox/lox (Kras;p...
ORGANISM(S): Mus musculus 
2015-09-20 | E-GEOD-64836 | biostudies-arrayexpress
TranscriptomicsCombination of ABT-869 with SAHA on AML with FLT3-ITD
For the microarray experiments, MV4-11 and MOLM-14 cells were treated with DMSO control, ABT-869 3 nM, SAHA 6 M and combination therapy for 24 hours. Cells were then washed in PBS and high-quality total RNA was extracted RNeasy Midi Kit, according to the manufacturer’s instruction (Qiagen, Valencia...
ORGANISM(S): Homo sapiens 
2011-05-31 | E-GEOD-26114 | biostudies-arrayexpress
ProteomicsEpigenetic Impairment of tumor potential of AML-derived extracellular vesicles
The biological active cargo of leukemia-derived extracellular vesicles (EVs) favours a wide variety of cancer-supportive mechanisms, including aberrant proliferative signalling, immune escape and drug resistance. However, whether and in which extent anti-neoplastic drugs affect EV cargo sorting is ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD042168 | Pride
Vesicle Leukemia Tumorigenicity Epigenetic Saha 
TranscriptomicsVascular histone deacetylation by pharmacological HDAC inhibition [SAHA, RNA-seq]
HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...
ORGANISM(S): Homo sapiens 
2014-02-23 | E-GEOD-54912 | biostudies-arrayexpress
TranscriptomicsGlobal mRNA expression profiling of patient derived pancreatic carcinoma xenograft Bo63 following JQ1-SAHA combination therapy
Global mRNA expression profiling of patient derived pancreatic carcinoma xenograft Bo63 were collected using Agilent human whole genome array (G4845A AMADID 026652, cRNA 4x44k V2) . Two different sources of RNA were analyzed: 1.) Bo63 xenograft tumors grown on nude mice treated with vehicle only as ...
ORGANISM(S): Homo sapiens 
2015-09-20 | E-GEOD-64837 | biostudies-arrayexpress
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