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ProteomicsPhosphoproteomic Characterization of Signaling Networks Resulting from Activation of Chemokine Receptor CCR2
Leukocyte recruitment, a universal feature of tissue inflammation, is regulated by the interactions of chemokines with their G protein-coupled receptors. Activation of CC chemokine receptor 2 (CCR2) by its cognate chemokine ligands, including CCL2, plays a central role in recruitment of monocytes in...
ORGANISM(S): Homo sapiens (Human) 
2020-04-08 | PXD015845 | Pride
Ccr2 Dia Phosphoproteomics Signalling 
TranscriptomicsTranscriptome comparison between CCR2+ and CCR2- classical monocytes in SIV-infected Macaca nemestrina
Monocytes have been categorized in three main subpopulations based on CD14 and CD16 surface expression. Classical monocytes are the most abundant subset in the blood. They express a CD14+CD16-CCR2+ phenotype, which confers on them the ability to migrate to inflammatory sites by quickly responding to...
ORGANISM(S): Macaca nemestrina 
2012-03-01 | E-GEOD-27559 | biostudies-arrayexpress
TranscriptomicsCCR2+ vs. CCR2- murine hematopoietic stem cells
Comparative analysis of FACS-sorted CCR2- and CCR2+ HSC in the steady state. CCR2+ HSC have fourfold higher proliferative rates than CCR2- HSC, are are biased towards the myeloid lineage and dominate the migratory HSC population. Comparison of pooled CCR2- and CCR2+ HSC (bone marrow from 20 mice poo...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-53827 | biostudies-arrayexpress
TranscriptomicsRole of CCR2+ myeloid cells in pancreatic β cell growth and regeneration
Pancreas and spleen were microdissected from wild type (C57B6/SV129 background) E14.5 embryos and P0 newborn pups. Pools of 30-60 tissues were used. Tissues were digested for 1 hour at 37°C in HBSS/0.1% collagenase A/20 µg/ml DNase I, followed by dissociation of the cell clusters into single cells...
ORGANISM(S): Mus musculus 
2017-12-06 | E-MTAB-5427 | biostudies-arrayexpress
GenomicsMus musculus strain:CCR2-GFP-C57BL/6J
Mus musculus strain:CCR2-GFP-C57BL/6J Transcriptome or Gene expression
PRJNA847069 | ENA
TranscriptomicsCCL2/CCR2-dependent recruitment of functional antigen-presenting cells into tumors post-chemotherapy
Analysis of MCA205 tumors developed in C57bl/6 mice on day 2, 7 and 10 after intratumoral treatment with doxorubicin (DX) or PBS solvent. DX triggers the immunogenicity of dying tumor cell and activates anti-tumor immunity. Results provided insight into molecular basis of DX induced immune response....
ORGANISM(S): Mus musculus 
2014-02-04 | E-GEOD-46275 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of wild type and CCR2-/- mice post chikungunya infection
A number of inhibitors of chemokine CCL2 and its receptor CCR2 are in development and may find application for treating a range of inflammatory conditions, including autoimmune and viral arthritides. Herein we sought to determine the effect of CCR2 deficiency on arthritis caused by an arthritogenic...
ORGANISM(S): Mus musculus 
2014-04-23 | E-GEOD-56965 | biostudies-arrayexpress
GenomicsTranscriptomic profile of dermal and hypodermal CCR2+ macrophages, CCR2- macrophages and dendritic cells from C57BL/6 mice
Transcriptomic profile of dermal and hypodermal CCR2+ macrophages, CCR2- macrophages and dendritic cells from C57BL/6 mice
PRJNA946769 | ENA
TranscriptomicsCCR2+ vs. CCR2- murine hematopoietic stem cells
Comparative analysis of FACS-sorted CCR2- and CCR2+ HSC in the steady state. CCR2+ HSC have fourfold higher proliferative rates than CCR2- HSC, are are biased towards the myeloid lineage and dominate the migratory HSC population.
ORGANISM(S): Mus musculus 
2015-05-01 | GSE53827 | GEO
GenomicsTranscriptome analysis of pulmonary CCR2+ inflammatory monocytes challenged with Cryptococcus neoformans
Transcriptome analysis of pulmonary CCR2+ inflammatory monocytes challenged with Cryptococcus neoformans
PRJNA506250 | ENA
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