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TranscriptomicsDifferential Gene expression in CCR5+ versus CCR5- OT-I T cells
OT-I T cells were exposed to CpG ODN-activated CCR5ko Lymph nodes for 6 h, stained for surface CCR5 and FACS-sorted into CCR5+ and CCR5- fractions In the study presented here freshly isolated OT1 T cells were exposed for 6h at 37oC to teased-out CpG ODN-activated CCR5ko LNs in 96-well plates and sta...
ORGANISM(S): Mus musculus 
2016-01-14 | E-GEOD-76820 | biostudies-arrayexpress
TranscriptomicsCCR5 controls neuronal damage in an in vivo model of HIV glycoprotein 120-induced brain injury
The chemokine receptor CCR5 is a major co-receptor for human immunodeficiency virus 1 (HIV-1) mediating infection of target cells1,2. Beyond its function as co-receptor, CCR5 also influences the course of HIV disease and progression to AIDS3. However, it is unclear how CCR5 affects HIV-associated da...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-47029 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteomic profiling of CCL5/CCR5 signaling cascade in melanoma cells
The CCL5/CCR5 axis plays a pivotal role in tumor progression and metastasis. We previously reported CCR5 promotes melanoma EMT and metastasis by upregulating TGFβ1 expression via the PI3K/AKT/GSK3β pathway. However, the full spectrum of downstream events triggered by CCR5 activation remains poorly u...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-14 | PXD066097 | Pride
ProteomicsPeople with HIV have higher percentages of circulating CCR5+ CD8+ T cells and lower percentages of CCR5+ regulatory T cells
CCR5 is the main HIV co-receptor. We aimed to (1) compare CCR5 expression on immune cells between people living with HIV (PLHIV) using combination antiretroviral therapy (cART) and HIV-uninfected controls, (2) relate CCR5 expression to viral reservoir size and (3) assess detereminants of CCR5 expres...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031628 | Pride
Hiv-1 Ccr5 Inflammation Persistent infection 
GenomicsCCR5 HIV controllers
CCR5 HIV controllers
PRJEB48153 | ENA
ProteomicsCCR5_T30
To examine the signaling pathways active downstream ACKR2, both in constitutive and ligand-stimulated conditions, we carried out a large-scale mass spec-based quantitative phosphoproteomic analysis by SILAC technique. ACKR2 has been expressed in HEK293T cells using a tetracycline-inducible system an...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD009908 | Pride
Ccr5 t30 phosphoproteomics silac 
ProteomicsCCR5_T0
To examine the signaling pathways active downstream ACKR2, both in constitutive and ligand-stimulated conditions, we carried out a large-scale mass spec-based quantitative phosphoproteomic analysis by SILAC technique. ACKR2 has been expressed in HEK293T cells using a tetracycline-inducible system an...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD009866 | Pride
Phosphoproteomics silac ccr5 t0 
GenomicsCCR5 HIV controllers
Sequencing of 9kb of the CCR5 genomic locus in 15 patients who naturally control HIV infection
ORGANISM(S): Homo sapiens 
2021-12-07 | E-MTAB-11062 | biostudies-arrayexpress
TranscriptomicsGene Expression in wild type and CCR5 knockout mice with lung metastasis
We have shown that C57BL/6J CCR5 knockout mice develop 30.4% ± 8.6% fewer B16 F10 lung nodules compared to wild type mice after the intravenous injection of 100,000 B16 F10 cells. We sought to understand this phenomenon by comparing gene expression in the lungs of these mice at 6, 24, and 48 hours...
ORGANISM(S): Mus musculus 
2013-10-25 | E-GEOD-51422 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human peripheral blood B helper T-cell subsets
Human T-cells that express CXCR5 and/or CCR6 provide help to naive B-cells for IgG production. To understand the molecular pathways that are shared or unique to individual B helper T-cell subsets in human peripheral blood, CD4+IL-7R+CD25-/lo helper T-cells were purified according to the expression o...
ORGANISM(S): Homo sapiens 
2020-03-11 | E-MTAB-8862 | biostudies-arrayexpress
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