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TranscriptomicsCCRF-CEM Prednisolone treatment at 4h
Background: Glucocorticoids are important pharmaceutical agents in the treatment of acute lymphoblastic leukemia in children. Resistance or sensitivity to glucocorticoids is considered to be of crucial importance for disease prognosis. Prednisolone is a first-line chemotherapeutic agent in the treat...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-27989 | biostudies-arrayexpress
TranscriptomicsExpression data from glucocorticoid-treated ALL (CCRF-CEM-C7-14 cells)
The beneficial effects of glucocorticoids (GCs) in acute lymphoblastic leukemia (ALL) are based on their ability to induce apoptosis. Omics technologies such as DNA microarray analysis are widely used to study the changes in gene expression and have been successfully implemented in biomarker identif...
ORGANISM(S): Homo sapiens 
2012-09-01 | E-GEOD-39338 | biostudies-arrayexpress
TranscriptomicsCCRF-CEM Prednisolone and MG132 treatments at 4h
Background: The combination of Proteasome inhibitor with Glucocorticoid is one of the most promising antileukemic treatments. Both agents act through pluripotent signal mediators. The two types of agents inhibit key signals that are considered crucial to their effects on malignant cells. Methodology...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-29136 | biostudies-arrayexpress
TranscriptomicsBortezomib resistance in CCRF-CEM cell line [miRNA]
Bortezomib is a proteasome inhibitor used in severel different hematological malignancies. Resistance to this drug is still poorly understood. In order get more insight in the resistance mechanism, we developed several bortezomib resistant subclones of the CCRF-CEM T-ALL cell line. On these subclone...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-74632 | biostudies-arrayexpress
TranscriptomicsBortezomib resistance in CCRF-CEM cell line [GEP]
Bortezomib is a proteasome inhibitor used in severel different hematological malignancies. Resistance to this drug is still poorly understood. In order get more insight in the resistance mechanism, we developed several bortezomib resistant subclones of the CCRF-CEM T-ALL cell line. On these subclone...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-74634 | biostudies-arrayexpress
TranscriptomicsBortezomib resistance in CCRF-CEM cell line [CGH]
Bortezomib is a proteasome inhibitor used in severel different hematological malignancies. Resistance to this drug is still poorly understood. In order get more insight in the resistance mechanism, we developed several bortezomib resistant subclones of the CCRF-CEM T-ALL cell line. On these subclone...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-74633 | biostudies-arrayexpress
TranscriptomicsPathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcomatic cells: a systems biology approach
A part of current research has intensively been focused on the proliferation and metabolic processes governing biological systems. Since the advent of high throughput methodologies like microarrays, the load of genomic data has increased geometrically and along with that the need for computational m...
ORGANISM(S): Homo sapiens 
2011-12-20 | E-GEOD-34522 | biostudies-arrayexpress
ProteomicsAsparaginase and GSK3A inhibitor treatment of CCRF-CEM cells
Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a synthetic lethal interaction between Wnt pathway activation and asparaginase in acute leukemias resistant to this enzyme. Wnt pathway activa...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD013061 | Pride
Gsk3 Leukemia Asparaginase 
GenomicsGenome-wide identification of genes directly regualted by GFI1 and IKAROS in CCRF-CEM cells
Genome-wide identification of genes directly regualted by GFI1 and IKAROS in CCRF-CEM cells
PRJNA672151 | ENA
GenomicsExpression data changes induced by 3D conditions in T-ALL cells [CCRF-CEM cells]
Expression data changes induced by 3D conditions in T-ALL cells [CCRF-CEM cells]
PRJNA788450 | ENA
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