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MetabolomicsInvestigating diet to control asparagine uptake as an adjunct to asparaginase treatment

Refinements of multidrug regimens, and particularly the addition of L-asparaginase, resulted in an immediate gain in survival for pediatric acute lymphoblastic leukemia patients. Yet L-asparaginase has substantial side effects which may require dose reductions or delays in subsequent doses. There...

2026-01-25 | MTBLS13764 | MetaboLights
ProteomicsAsparaginase and GSK3A inhibitor treatment of CCRF-CEM cells
Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a synthetic lethal interaction between Wnt pathway activation and asparaginase in acute leukemias resistant to this enzyme. Wnt pathway activa...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD013061 | Pride
Gsk3 Leukemia Asparaginase 
TranscriptomicsClinical acute lymphoblastic leukemia samples (untreated) with known asparaginase LC50 values
Samples of pediatric acute lymphoblastic leukemia obtained from patients at diagnosis. All samples contain at least 77% blasts. Asparaginase LC50 values were determined for each of these samples. (LC50 was determined on a different aliquot of the same sample.) Set of arrays organized by shared bio...
ORGANISM(S): Homo sapiens 
2006-01-20 | E-GEOD-4070 | biostudies-arrayexpress
TranscriptomicsIn vitro response to l-asparaginase in acute lymphoblastic leukemia
This SuperSeries is composed of the following subset Series: GSE4070: Clinical acute lymphoblastic leukemia samples (untreated) with known asparaginase LC50 values GSE4071: Clinical pediatric acute lymphoblastic leukemia samples after in vitro exposure to L-asparaginase GSE4072: L-asparaginase expo...
ORGANISM(S): Homo sapiens 
2006-03-07 | E-GEOD-4397 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human L-asparaginase drug resistant acute lymphoblastic leukemia cells
primary ALL cells (B- and T-lineage) resistant to L-asparaginase by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-645 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary ALL cells (B-lineage) sensitive to L-asparaginase by the MTT in vitro sensitivity assay
primary ALL cells (B-lineage) sensitive to L-asparaginase by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-653 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary ALL cells (B-lineage) resistant to L-asparaginase by the MTT in vitro sensitivity assay
primary ALL cells (B-lineage) resistant to L-asparaginase by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-654 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ALL exhibiting cross-resistance to prednisolone, vincristine, asparaginase and daunorubicinchemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) can be cured with combination chemotherapy in over 75% of children, but the cause of treatment failure in the remaining patients is unknown. We determined the sensitivity of ALL cells to individual antileukemic agents in 441 patients, and used a genome-wide approac...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2351 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary ALL cells (B- and T-lineage) sensitive to L-asparaginase by the MTT in vitro sensitivity assay
primary ALL cells (B- and T-lineage) sensitive to L-asparaginase by the MTT in vitro sensitivity assay
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-643 | biostudies-arrayexpress
TranscriptomicsL-asparaginase exposure in acute lymphoblastic leukemia cell lines time series
Time series of in vitro 2 IU/ml L-asparaginase exposure in acute lymphoblastic leukemia cell lines. Groups of assays that are related as part of a time series. Using regression correlation
ORGANISM(S): Homo sapiens 
2006-01-20 | E-GEOD-4072 | biostudies-arrayexpress
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