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TranscriptomicsGeneration of clinical grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of B-cell malignancies
Long-lived, self-renewing, multipotent T memory stem cells (TSCM) can trigger profound and sustained tumor regression but their rareness poses a major hurdle to their clinical application. Presently, clinically compliant procedures to generate relevant numbers of this T cell population are undefined...
ORGANISM(S): Homo sapiens 
2016-06-29 | E-GEOD-68003 | biostudies-arrayexpress
ProteomicsProteomic changes of CD19+ B Lymphocytes in COVID-19 Patients
The immune response to SARS-CoV-2 varies among patients. We used proteomic analysis to study CD19+ lymphocytes, which are important for the immune response. By comparing the proteomes of CD19+ cells from healthy individuals and COVID-19 patients, we discovered proteins and signaling pathways involve...
ORGANISM(S): Homo sapiens (Human) 
2023-09-24 | PXD042938 | Pride
Cd19+ Human Covid-19 Lymphocytes 
TranscriptomicsAcquired genomic copy number aberrations and survival in chronic lymphocytic leukemia
Genomic aberrations are of predominant importance to the biology and clinical outcome of patients with chronic lymphocytic leukemia (CLL), and FISH-based genomic risk classifications are routinely used in clinical decision making in CLL. One of the known limitations of CLL FISH is the inability to ...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-30777 | biostudies-arrayexpress
GenomicsKlebsiella pneumoniae strain:CD19 | isolate:CD19
Klebsiella pneumoniae strain:CD19 | isolate:CD19 Genome sequencing and assembly
PRJNA1293911 | ENA
GenomicsKlebsiella pneumoniae strain:CD19 | isolate:CD19
Klebsiella pneumoniae strain:CD19 | isolate:CD19 Genome sequencing and assembly
PRJNA1289395 | ENA
TranscriptomicsGene expression data from WT and Klf3 KO mouse CD19+ splenic B cells
To investigate the roles of Klf3 in B lymphopoiesis, CD19+ B cells were sorted from the spleens of WT and Klf3 KO mice (Molecular and Cellular Biology (2008); 28:3967–3978). Following RNA extraction, gene expression was compared in WT and Klf3 KO CD19+splenic B cells using Affymetrix microarrays. 4 ...
ORGANISM(S): Mus musculus 
2011-08-25 | E-GEOD-31622 | biostudies-arrayexpress
TranscriptomicsExpression data from long-term Ebf1-deficient, CD19+, Bcl2tg cells
An assessment of a role of Ebf1 in committed B lineage cells. In this study, we adopted the strategy of deleting Ebf1 after reconstitution of Rag2-/-Il2rg-/- mice and found that committed pre-B cells could be converted into T cells and ILCs upon deletion of Ebf1. We used µ-arrays to gain insight int...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-46349 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of four mouse bone marrow hematopoietic stem cells (HSC) early B lineage stages(MLP, CLP, Fr.A, Fr.B) to identify coordinately regulated gene as cells progress down the B cell development pathway
Differentiation from hematopoietic stem cells (HSC) to early B-lineage cells proceeds through a series of intermediate stages, during which cells are thought to become progressively more restricted in their developmental potential. RNAs were prepared from four early B lineage stages(MLP, CLP, Fr.A, ...
ORGANISM(S): Mus musculus 
2006-12-16 | E-MEXP-559 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of phenotypically defined human B cell subsets
Separation of B cells has been historically important in discovering their functional relevance, particularly in relation to infection, immune disorders and vaccination. Traditional use of phenotypic markers often poses problems in distinguishing heterogeneous populations such as the Double Negative...
ORGANISM(S): Homo sapiens 
2021-03-19 | E-MTAB-9544 | biostudies-arrayexpress
TranscriptomicsComparison of the DNA methylation profiles of CD19+ B lymphocytes of a pair of monozygotic twins discordant for common variable immunodeficiency
The methylation profiles of bisulfite-modified DNA of CD19+ cells from MZ twins discordant for CVID were compared using the Infinium HumanMethylation450 BeadChips (Illumina, Inc., San Diego, CA,). This platform allows the interrogation of >485,000 methylation sites per sample at single-nucleotide re...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-63849 | biostudies-arrayexpress
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