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GenomicsAcetivibrio cellulolyticus CD2
Acetivibrio cellulolyticus CD2 genome sequencing project.
PRJNA45843 | ENA
TranscriptomicsCD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions
Plasmacytoid dendritic cells (pDCs) are key regulators of anti-viral immunity. They rapidly secrete IFN-alpha and cross-present viral antigens thereby launching adaptive immunity. Here we show that activated human pDCs inhibit replication of cancer cells, and kill them in a contact dependent fashion...
ORGANISM(S): Homo sapiens 
2009-05-21 | E-GEOD-15215 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood CD2+ leukocytes from PATH particpants
Gene expression profiling was carried out on peripheral blood CD2+ leukocytes from 29 children with asthma. The primary research question is whether gene expression differs in individuals from high socioeconomic status environments vs low socioeconomic status environments. Experiment Overall Design...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-7894 | biostudies-arrayexpress
GenomicsStenotrophomonas sp. CD2 isolate:soil
Stenotrophomonas sp. CD2 isolate:soil Genome sequencing
PRJNA856778 | ENA
ProteomicsAnalysis of CD2 interactome in primary murine CD4+ T cells
CD2 is a receptor expressed on T cells and when engaged, it promotes T cell activation. However the mechanisms and molecular partners of CD2 that mediate T cell activation remain unclear. Here we used AP-MS to determine the interactome of CD2 prior and upon its engagement. For this purpose, we used ...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-12 | PXD029750 | Pride
Cd2 Ap-ms Mouse Primary cd4+ t cell Interactome Ost tag 
ProteomicsPhosphoproteomic analysis of CD2 signaling reveals an AMPK-dependent targeted granule secretion in human cytotoxic T cells
The in-depth analysis of co-stimulatory signaling enhancing the activity of cytotoxic T cells represents a major approach towards the development of immunotherapies. Here we describe that CD2 co-stimulation plays a critical role in the functioning of human cytotoxic T cells (CTLs). We found that CD2...
ORGANISM(S): Homo sapiens (Human) 
2020-04-28 | PXD013840 | Pride
Cd2 Phosphoproteome Granule secretion 
TranscriptomicsCD8 in vitro CD2-costimulation
Purified primary human CD8 T cells were stimulated in vitro in parallel using a magnetic bead conjugated to either anti-CD3/28 or anti-CD2/3/28 antibodies. Cells were cultured for 6 days in complete RPMI1640 and 10ng/ml IL2 and were harvested on day 6 and RNA was isolated for further labelling and ...
ORGANISM(S): Homo sapiens 
2015-08-12 | E-MTAB-3470 | biostudies-arrayexpress
TranscriptomicsRole of adhesion receptors in mast cell disease-evolution
Systemic mastocytosis (SM) is an incurable neoplasm characterized by abnormal accumulation of neoplastic mast cells (MC) in vascularized organs. In indolent SM, MC express several different adhesion-molecules including CD2 and CD58, and form focal tissue-aggregates, whereas in advanced SM, MC often ...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-33504 | biostudies-arrayexpress
GenomicsSingle-cell RNA sequencing of circulating mock-electroporated CD2 wild-type and CD2-knockout 41BBzeta CART19 cells
Single-cell RNA sequencing of circulating mock-electroporated CD2 wild-type and CD2-knockout 41BBzeta CART19 cells
PRJNA1413412 | ENA
TranscriptomicsHighly parallel assays of tissue-specific enhancers in whole Drosophila embryos
Understanding transcriptional regulatory networks requires the identification and characterization of cis-regulatory modules (CRMs), DNA sequences which can direct expression of associated genes to a specific cell type and/or developmental stage. Reporter assays for the capacity of a candidate CRM ...
ORGANISM(S): Drosophila melanogaster 
2013-07-13 | E-GEOD-41503 | biostudies-arrayexpress
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