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MetabolomicsComparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells

Introduction

Chronic inflammation is a hallmark of chronic wounds and inflammatory skin diseases. Due to a hyperactive and prolonged inflammation triggered by proinflammatory immune cells, transitioning to the repair and healing phase is halted. T cells may exacerbate the proinflammatory mil...
2025-07-09 | MTBLS9800 | MetaboLights
MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
MetabolomicsExtracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights
no omics definedTranscription profiling of human CD8 T cells activated with CD3 or CD3-CD28 prior to retroviral transduction and different selection procedures (G418 or NGFR-MACS)n
effect of different T cell activations (CD3 and CD3-CD28) prior retroviral transduction and different selection procedures (G418 or NGFR-MACS)
ORGANISM(S): Homo sapiens 
2007-06-01 | E-MEXP-973 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Parp-1 deficient and wild type T cells following CD3 and CD3/CD28 activation
Primary T cells were isolated from spleen of Parp-1-/- and wild-type mice by magnetic depletion of non-T cells using a MACS Pan-T Cell isolation kit, according to the manufacturer´s instruction (Mintenyi Biotec, Bergisch Gladbach, Germany). Purity was assessed by flow cytometry analysis using antibo...
ORGANISM(S): Mus musculus 
2008-08-04 | E-MEXP-1237 | biostudies-arrayexpress
TranscriptomicsDynamics of Virus-specific CD8+ T cells in the Human Nasal Cavity
The goal of this experiment is to compare the transcriptomic profile of CD8+ T cells isolated from the nasal cavity and whole blood at two different state, baseline and CD3/28 activated. This will allow us to characterise the unique features of CD8+ T cells in the nasal cavity. We isolated CD8+CD4...
ORGANISM(S): Homo sapiens 
2025-08-23 | E-MTAB-15436 | biostudies-arrayexpress
TranscriptomicsCITE-seq of human blood CD8+ T cells
The purpose of the experiment was to investigate the differentiation state gradient among antigen-experienced CD8+ T cells in healthy human blood. This was a sub-goal within a larger experiment, which aimed to investigate the clonal relationship between CD8+ T cells in blood and skin of matched dono...
ORGANISM(S): Homo sapiens 
2023-06-30 | E-MTAB-13034 | biostudies-arrayexpress
TranscriptomicsRNA-seq of purified T cells treated with KY1044 + anti-CD3 against anti-CD3 treated controls
KY1044 is a human monoclonal IgG1 that selectively binds to Inducible T cell CO-stimulator (ICOS). The co-stimulatory effect of KY1044-stimulated human T cells was analysed by RNA sequencing (RNA seq). Purified pre-activated (ICOS+ve) T cells were stimulated with either KY1044 and anti-CD3 or anti-C...
ORGANISM(S): Homo sapiens 
2020-09-01 | E-MTAB-9500 | biostudies-arrayexpress
TranscriptomicsRNA-seq of T cells form house dust mite mouse model of bronchoalveolar lavage (BAL), medLN and lung tissues
This dataset profiles T cells recovered from the airway lumen (bronchoalveolar lavage, BAL), medLN and lung tissues of mice exposed to house dust mite (HDM) allergen, a model of allergic airway inflammation. The aim of this experiment was to capture, at single-cell resolution, both the transcription...
ORGANISM(S): Mus musculus 
2026-07-31 | E-MTAB-17402 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of kidney infiltrating T cells after ischemia reperfusion injury reveals a pathophysiologic role for the chemokine (C-C motif) receptor 5
We examined the transcriptional responses in kidney infiltrating T cells 6 hrs after IRI CD3 (+) T cells were purified applying magnetic beads to mononuclear cells extracted from kidney by percoll gradient methods. The total T-cell RNA was isolated, and trabscript abundance measured with array-based...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-23747 | biostudies-arrayexpress
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