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TranscriptomicsDefinition and characterization of the systemic T cell dysregulation in untreated indolent B cell lymphoma and very early CLL
Epidemiological data show that the immune system may control or promote emergence and growth of a neoplastic lymphomatous clone. Conversely, systemic lymphomas, especially myeloma and CLL, are associated with clinical immunodeficiency. This prospective controlled study demonstrates substantially red...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-23293 | biostudies-arrayexpress
TranscriptomicsGeneration and purification of Th1 and Th2 effector and memory CD4+ T cells
Naïve CD4+ T cells were isolated from spleen of AND TcR transgenic/green fluorescence protein (GFP) transgenic mice (Kaye et al., Nature 1989;341:746, Wright et al, Blood 2001;97:2278) that recognize a peptide of pigeon cytochrome C in the context of I-Ek and express CD44lo, CD62Lhi, CD45RBhi, and ...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-8352 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression in different T cell clones
The aim was to analyze the expression of genes in T cell clones having different functional profiles (Th1, Th0, Th17, Th2) obtained from the same individual. Keywords: Gene expression, T cell clones, Th17 characterisation The T cell clones were derived according to well known protocol, using differ...
ORGANISM(S): Homo sapiens 
2008-05-30 | E-GEOD-11553 | biostudies-arrayexpress
TranscriptomicsEvaluation of effect of PTEN gene deletion in mouse CD4+ Th1 clones after stimulation
PTEN is thought to play a critical role in T cell activation by negatively regulating the PI3K signaling pathway important for cellular activation, growth, and proliferation. T cells from mice in which PTEN was conditionally deleted in the thymus were reported to display CD28-independent IL-2 produ...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-43936 | biostudies-arrayexpress
TranscriptomicsComparison of bovine gd and ab T cell clones
Comparison of gd T cell clones with ab T cell clones that responded to the same antigen. Clones were identically stimulated with ConA/IL-2 and analyzed with two separate microarrays. Keywords: other
ORGANISM(S): Bos taurus 
2010-06-09 | E-GEOD-2704 | biostudies-arrayexpress
TranscriptomicsRNA-seq of T cells form house dust mite mouse model of bronchoalveolar lavage (BAL), medLN and lung tissues
This dataset profiles T cells recovered from the airway lumen (bronchoalveolar lavage, BAL), medLN and lung tissues of mice exposed to house dust mite (HDM) allergen, a model of allergic airway inflammation. The aim of this experiment was to capture, at single-cell resolution, both the transcription...
ORGANISM(S): Mus musculus 
2026-07-31 | E-MTAB-17402 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Th1, Th2, Th9, and Th17 T cell clones
We next sought to identify the transcriptional program that differentiates IL-9+Th2 cells from “conventional” Th2 cells. To this end, we selected representative Th1, Th17, Th2, and IL-9+Th2 clones (Figure 5A) and determined their transcriptome in the resting state and at different time points after ...
ORGANISM(S): Homo sapiens 
2017-11-10 | E-MTAB-5739 | biostudies-arrayexpress
TranscriptomicsExpression data from human CD4 or CD8 T-cells isolated from PBMC cultured at a low cell density (LDC) or high cell density (HDC)
Research in human immunobiology is mainly based on working with peripheral blood mononuclear cells (PBMC). However, recent investigations have shown that circulating CD4+ T cells are less sensitive to several T-cell activating monoclonal antibodies (mAb) and to recall antigens as compared to tissue-...
ORGANISM(S): Homo sapiens 
2015-06-09 | E-GEOD-51288 | biostudies-arrayexpress
TranscriptomicsTranscriptional correlates of FOXP3 expression in suppressive and non-suppressive primary human Treg cell clones.
Analysis of the transcriptional correlates of FOXP3 expression in suppressive and non-suppressive primary human Treg cell clones. Individual CD4+CD25High or Cd4+CD25- T cells were isolated from human PBMCs and expanded in vitro. After 3 weeks of expansion, individual clones were analysed for FOXP3 e...
ORGANISM(S): Homo sapiens 
2015-05-06 | E-GEOD-65650 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human Th9 T cell clones treated with GW9662 against untreated control
To investigate the role of PPAR-γ in human TH cells, transcriptional response of activated “TH9” clones to treatment with GW9662, a potent PPAR-γ antagonist was assessed. “TH9” cell clones were incubated with GW9662 for 48h and activated with αCD3/2/28 for 12 h. Transcriptomic profiling was performe...
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12197 | biostudies-arrayexpress
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