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ProteomicsCD70 Regulates the NF1/Ras/ERK Axis to Promote Metastatic Potential in Clear Cell Renal Cell Carcinoma
This study is the first report demonstrating a novel mechanism by which CD70 promotes clear cell renal cell carcinoma (ccRCC) progression and metastasis, at least in part, through suppression of NF1 and subsequent activation of the Ras/ERK signaling pathway, which may further drive EMT-related featu...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD069813 | Pride
Emt Cd70 Nf1 Combination therapy Ras/erk pathway Proteomics Metastasis Ccrcc 
GenomicsClostridioides difficile CD70
Clostridioides difficile CD70 Genome sequencing and assembly
PRJNA85723 | ENA
GenomicsAnalysis of CD70 wild type or CD70 knock out CD70-specific nanoCAR T cells
Analysis of CD70 wild type or CD70 knock out CD70-specific nanoCAR T cells
PRJNA945042 | ENA
TranscriptomicsTranscription profiling by array of mouse wild type or CD27-/- OT-I T cells are stimulated with artficial antigen presenting cell lines expressing CD70 and/or CD80
WT or CD27-/- OT-I T cells are stimulated in vitro with artficial antigen presenting cell (aAPC) lines expressing CD70 and/or CD80 for 2, 4, 8 or 14 hours.
ORGANISM(S): Mus musculus 
2010-09-29 | E-NCMF-38 | biostudies-arrayexpress
GenomicsAnalysis of CD70 wild type or CD70 knock out CD70-specific nanoCAR T cells [RNA-Seq]
Analysis of CD70 wild type or CD70 knock out CD70-specific nanoCAR T cells [RNA-Seq]
PRJNA1105004 | ENA
GenomicsRNA sequencing analysis of ex vivo expanded CD27+CD70- and CD27-CD70+ human regulatory T cells
RNA sequencing analysis of ex vivo expanded CD27+CD70- and CD27-CD70+ human regulatory T cells
PRJNA530612 | ENA
TranscriptomicsAnalysis of CD70 wild type or CD70 knock out CD70-specific nanoCAR T cells
CD70 is an attractive target for chimeric antigen receptor (CAR) T cell therapy as treatment for both solid and liquid malignancies. However, functionality of CD70-specific CAR T cells is only modest. Here, we optimized a CD70-specific VHH based CAR (nanoCAR). We evaluated the nanoCARs in clinically...
ORGANISM(S): Homo sapiens 
2024-06-17 | GSE227435 | GEO
TranscriptomicsAnalysis of CD70 wild type or CD70 knock out CD70-specific nanoCAR T cells [RNA-Seq]
CD70 is an attractive target for chimeric antigen receptor (CAR) T-cell therapy for the treatment of both solid and liquid malignancies. However, the functionality of CD70-specific CAR T-cells is modest. We optimized a CD70-specific VHH-based CAR (nanoCAR). We evaluated the nanoCARs in clinically re...
ORGANISM(S): Homo sapiens 
2024-06-17 | GSE265937 | GEO
GenomicsCUT&RUN profiling of EZH2, H3K27me3, and H3K4me3 enrichment in FACS-sorted CD70⁻ and CD70⁺ tumor cells from untreated ex vivo ccRCC and HGSOC patient-derived xenografts.
CUT&RUN profiling of EZH2, H3K27me3, and H3K4me3 enrichment in FACS-sorted CD70⁻ and CD70⁺ tumor cells from untreated ex vivo ccRCC and HGSOC patient-derived xenografts.
PRJNA1368670 | ENA
GenomicsSensitive CAR T cells redefine targetable CD70 expression in solid tumors [ATAC-seq]
Sensitive CAR T cells redefine targetable CD70 expression in solid tumors [ATAC-seq]
PRJNA1368650 | ENA
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