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GenomicsCD95L mRNA is toxic to cells
CD95L mRNA is toxic to cells
PRJNA471325 | ENA
TranscriptomicsExpression data from mNSc after 48 hour of treatment with CD95L-T4
In neural stem cells, stimulation of the â??death receptorâ?? CD95 does not trigger apoptosis but resulted in increased stem cell survival and neuronal specification via activation of the Src /PI3K /AKT/mTOR signalling pathway. To further characterize CD95-dependent neural stem cell survival and dif...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-15623 | biostudies-arrayexpress
UnknownThe dual role of the CD95 and CD95L signaling pathway in glioblastoma.
Not available
S-EPMC9730406 | biostudies-literature
UnknownTherapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases.
Not available
S-EPMC8931059 | biostudies-literature
TranscriptomicsExpression data from cleaved CD95L treated human Th17 and Treg cells.
Th17 and Treg cells show a different infiltration and migrations pattern in inflamed skin from systemic lupus erythematosus patients. This distribution strongly correlates with the plasm levels of cleaved CD95L (cl-CD95L). To identify the mechanisms that underly this difference in migration, we used...
ORGANISM(S): Homo sapiens 
2016-03-05 | GSE78909 | GEO
UnknownA Novel Tetravalent CD95/Fas Fusion Protein With Superior CD95L/FasL Antagonism.
Not available
S-EPMC11694555 | biostudies-literature
GenomicsCD95L mRNA is toxic to cells
>80% of a large number of tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death that is characterized by the simultaneous activation of multiple death pathways and preferentially affects transformed and cancer stem cells. We now show that these si/shRNAs kill can...
ORGANISM(S): Homo sapiens 
2018-09-21 | GSE114425 | GEO
UnknownTRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis.
Not available
S-EPMC4649511 | biostudies-literature
OtherCD95L mRNA is toxic to cells [SmallRNA_AGOpulldownCD95L_50hrs_HeyA8_CD95KO]
>80% of a large number of tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death that is characterized by the simultaneous activation of multiple death pathways and preferentially affects transformed and cancer stem cells. We now show that these si/shRNAs kill can...
ORGANISM(S): Homo sapiens 
2018-09-20 | GSE102777 | GEO
ProteomicsMetalloprotease-mediated cleavage of CD95 Ligand: QTOF Xevo XS data
CD95 is a member of the TNF receptor superfamily that is ubiquitously expressed in healthy and pathological tissues. Stimulation of CD95 by its physiological ligand CD95L induces its oligomerization leading in turn to the transduction of either apoptotic or non-apoptotic signals. CD95L can exist as ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-20 | PXD039211 | Pride
Cd95l Metalloprotease Proteolytic cleavage 
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