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ProteomicsCDC14B interactome - The proteomic approach aimed at the identification of interaction partners for the human dual phosphatase and tumor suppressor CDC14B by Co-inmunoprecipitation (Co-IP) experiments. In this approach, CDC14B interactomes from unsynchronized and G2/M enriched cells were compared semi-quantitatively based on spectral counting. This approach yielded the deubiquitylase USP9X as a G2/M-specific CDC14B interactor which has been confirmed by Western-blot (WB).
The proteomic approach aimed at the identification of interaction partners for the human dual phosphatase and tumor suppressor CDC14B by Co-inmunoprecipitation (Co-IP) experiments. In this approach, CDC14B interactomes from unsynchronized and G2/M enriched cells were compared semi-quantitatively bas...
ORGANISM(S): Homo sapiens (Human) 
2020-03-25 | PXD012732 | Pride
Usp9x Cdc14b 
ProteomicsUSP9X phosphopeptide mapping - We previously identified the deubiquitylase USP9X as a G2/M-specific CDC14B interactor (PXD012732). The functional connection of these proteins has been further investigated by a quantitative comparison of USP9X phosphorylation in WT vs CDC14B-overexpressing HEK 293Tcells (ATCC® CRL-3216™). The approach identified USP9X serine 2563 as a specific CDC14B target. Phosphorylation at USP9XS2563 has been confirmed by in-house phosphospecific antibodies.
We previously identified the deubiquitylase USP9X as a G2/M-specific CDC14B interactor (PXD012732). The functional connection of these proteins has been further investigated by a quantitative comparison of USP9X phosphorylation in WT vs CDC14B-overexpressing HEK 293Tcells (ATCC® CRL-3216™). The appr...
ORGANISM(S): Homo sapiens (Human) 
2020-03-25 | PXD012733 | Pride
Cdc14b Usp9x 
UnknownThe dual-specificity phosphatase CDC14B bundles and stabilizes microtubules.
Not available
S-EPMC1140622 | biostudies-literature
UnknownMatrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B.
Not available
S-EPMC10132239 | biostudies-literature
GenomicsMatrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B [Iso-Seq]
Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B [Iso-Seq]
PRJNA846341 | ENA
GenomicsMatrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B [PAR-CLIP]
Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B [PAR-CLIP]
PRJNA841187 | ENA
GenomicsMatrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B [polyA capture]
Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B [polyA capture]
PRJNA841188 | ENA
GenomicsMatrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B [Ribo-deplete]
Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B [Ribo-deplete]
PRJNA841185 | ENA
UnknownCDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes.
Not available
S-EPMC2804832 | biostudies-literature
TranscriptomicsMatrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B [polyA capture]
Purpose: Matrin3 (MATR3) is a DNA and RNA-binding protein and one of the major components of the nuclear matrix. Matrin3 is upregulated in colorectal cancer (CRC) compared to normal tissues, indicating potential oncogenic function in CRC. We found that depletion of Matrin3 results in decreased proli...
ORGANISM(S): Homo sapiens 
2023-03-17 | GSE203519 | GEO
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