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ProteomicsMouse CDC73 AP-MS in AML - PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia
Here we performed AP-MS experiments to find novel binding partners of CDC73 in mouse M1 AML cells. We also utilized a CDC73 mutant that does not support AML cell growth to determine functional consequences of gainin/ losing protein-protein interactions on mutation of this protein.
ORGANISM(S): Mus musculus (Mouse) 
2018-05-22 | PXD009439 | Pride
Ap-ms Mutation study Cdc73 
TranscriptomicsExpression analysis of zebrafish TIF1g-deficient, cdc73 deficient and double-deficient embryos
Investigation of whole genome gene expression level changes in zebrafish TIF1g-deficient, cdc73 deficient and double-deficient embryos, compared to the wild-type ebryos. A twelve-chip study using total RNA isolated from gata1-GFP positive cells (sorted by FACS) from 12 somite-stage wild type embryos...
ORGANISM(S): Danio rerio 
2010-07-13 | E-GEOD-20432 | biostudies-arrayexpress
GenomicsSaccharomyces cerevisiae S288C
Saccharomyces cerevisiae cdc73, tel1 cdc73, and yku80 cdc73 GCR sequencing
PRJNA386321 | ENA
GenomicsRNA-seq for UBR5 and Cdc73-regulated genes in 4T1 cells treated with Dovitinib
RNA-seq for UBR5 and Cdc73-regulated genes in 4T1 cells treated with Dovitinib
PRJNA923364 | ENA
GenomicsIntegrated single-cell and genomic analysis reveals CDC73-centered malignant reprogramming in parathyroid carcinoma
Integrated single-cell and genomic analysis reveals CDC73-centered malignant reprogramming in parathyroid carcinoma
PRJNA1438107 | ENA
UnknownLarge deletion at the CDC73 gene locus and search for predictive markers of the presence of a CDC73 genetic lesion.
Not available
S-EPMC5945533 | biostudies-literature
UnknownCdc73 suppresses genome instability by mediating telomere homeostasis.
Not available
S-EPMC5779705 | biostudies-literature
UnknownGenotype of CDC73 germline mutation determines risk of parathyroid cancer.
Not available
S-EPMC8802173 | biostudies-literature
UnknownUBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer.
Not available
S-EPMC9098409 | biostudies-literature
GenomicsCdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress [ChIP-seq]
Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress [ChIP-seq]
PRJNA913932 | ENA
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