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ProteomicsEvidence for substrate control of Cdk phosphorylation timing during the budding yeast cell cycle1757
The main intention of this project is to investigate how Cdk substrate phosphorylation is ordered during the cell cycle. We want to understand what makes a ‘good’ Cdk substrate that is phosphorylated early during the cell cycle, e. g. to promote S phase, as compared to a ‘bad’ Cdk substrate that is ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-10 | PXD054832 | Pride
Phosphoproteomics Cdk inhibition Tmt Cdk Cell cycle 
ProteomicsEvidence for substrate control of Cdk phosphorylation timing during the budding yeast cell cycle 3344
The main intention of this project is to investigate how Cdk substrate phosphorylation is ordered during the cell cycle. We want to understand what makes a ‘good’ Cdk substrate that is phosphorylated early during the cell cycle, e. g. to promote S phase, as compared to a ‘bad’ Cdk substrate that is ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-10 | PXD054870 | Pride
Phosphoproteomics Cdk inhibition Tmt Cdk Cell cycle 
ProteomicsEvidence for substrate control of Cdk phosphorylation timing during the budding yeast cell cycle 3174
The main intention of this project is to investigate how Cdk substrate phosphorylation is ordered during the cell cycle. We want to understand what makes a ‘good’ Cdk substrate that is phosphorylated early during the cell cycle, e. g. to promote S phase, as compared to a ‘bad’ Cdk substrate that is ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-10 | PXD055238 | Pride
Phosphoproteomics Tmt Cdk Cell cycle 
ProteomicsEvidence for substrate control of Cdk phosphorylation timing during the budding yeast cell cycle 2522
The main intention of this project is to investigate how Cdk substrate phosphorylation is ordered during the cell cycle. We want to understand what makes a ‘good’ Cdk substrate that is phosphorylated early during the cell cycle, e. g. to promote S phase, as compared to a ‘bad’ Cdk substrate that is ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-10 | PXD054974 | Pride
Phosphoproteomics Tmt Cdk Cell cycle 
ProteomicsCyclin Specificity Governs Centrosomal Cyclin/CDK Localisation and is Necessary for the G2/M Transition
In eukaryotes, cyclin/CDK complexes drive cells through DNA replication and mitosis, establising cell cycle temporal order. The fission yeast S. pombe is able to function with a single cyclin/CDK complex, with cell cycle order emerging from differential substrate sensitivities to CDK activity. What ...
ORGANISM(S): Schizosaccharomyces pombe 927 
2019-05-27 | PXD011987 | Pride
Cdk mitosis tmt phosphorylation 
ProteomicsEvidence for substrate control of Cdk phosphorylation timing during the budding yeast cell cycle 2305
The main intention of this project is to investigate how Cdk substrate phosphorylation is ordered during the cell cycle. We want to understand what makes a ‘good’ Cdk substrate that is phosphorylated early during the cell cycle, e. g. to promote S phase, as compared to a ‘bad’ Cdk substrate that is ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-10 | PXD054725 | Pride
Phosphoproteomics Tmt Cdk Cell cycle 
ProteomicsEvidence for substrate control of Cdk phosphorylation timing during the budding yeast cell cycle 3270
The main intention of this project is to investigate how Cdk substrate phosphorylation is ordered during the cell cycle. We want to understand what makes a ‘good’ Cdk substrate that is phosphorylated early during the cell cycle, e. g. to promote S phase, as compared to a ‘bad’ Cdk substrate that is ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-10 | PXD054772 | Pride
Phosphoproteomics Tmt Cdk Cell cycle 
ProteomicsBudding yeast relies on qualitative G1 cyclin specificity to couple cell cycle progression with morphogenetic development
Two models have been put forward for cyclin-dependent kinase (Cdk) control of the cell cycle. In the qualitative model, cell cycle events are ordered by distinct substrate specificities associated with successive waves of G1, S and mitotic cyclins. Alternatively, the gradual quantitative rise of Cdk...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-23 | PXD022757 | Pride
Lc-ms/ms Tmt Cdk Yeast Cyclin Cell cycle Phosphoproteomics Cyclin-dependent kinase 
ProteomicsRedundancy and Specialisation of Cyclin Dependent Kinases
Cyclin dependent kinases (CDKs) lie at the heart of eukaryotic cell division, with different CDK complexes initiating DNA replication (S-CDKs) and mitosis (M-CDKs)1-3. However, the principles on which cyclin-CDKs organise the cell cycle are still contentious, with current theories suggesting that ei...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2022-03-22 | PXD029073 | Pride
Phosphoproteomics Fission yeast Tmt S. pombe 
ProteomicsCdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit
Temporal control over protein phosphorylation and dephosphorylation is crucial for accurate chromosome segregation and for completion of the cell division cycle during exit from mitosis. In budding yeast, the Cdc14 phosphatase is thought to be a major regulator at this time, while in higher eukaryot...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-12 | PXD012860 | Pride
Tmt Pp2a Phosphatase Orbitrap Mitotosis Cdc14 
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