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ProteomicsDiscovery of covalent CDK14 inhibitors with pan-TAIRE family specificity
Cyclin dependent kinase 14 (CDK14) and other TAIRE family kinases (CDKs 15-18) are proteins that lack functional annotation but are frequent off-targets of clinical kinase inhibitors. In this study we develop and characterize FMF-04-159-2, the first tool compound that specifically targets CDK14 cova...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD012692 | Pride
Covalent inhibitor Druggable genome Mitosis Taire kinase Cell-cycle Cdk14 
GenomicsTranscriptome analysis of Scramble control and CDK14-sh MDA-MB-231 cells
Transcriptome analysis of Scramble control and CDK14-sh MDA-MB-231 cells
PRJNA808317 | ENA
GenomicsTranscriptome analysis of Scramble control and Cdk14-sh mouse mammary basal cells
Transcriptome analysis of Scramble control and Cdk14-sh mouse mammary basal cells
PRJNA832130 | ENA
TranscriptomicsTranscriptome analysis of Scramble control and Cdk14-sh mouse mammary basal cells
Wnt/β-catenin signaling pathway has become a key signaling pathway regulating mammary organogenesis and oncogenesis. However, the therapeutic methods by targeting Wnt pathway against breast cancer has been limited. To address this challenge, we investigated the function of cyclin-dependent kinase 14...
ORGANISM(S): Mus musculus 
2022-04-29 | GSE201526 | GEO
TranscriptomicsTranscriptome analysis of Scramble control and CDK14-sh MDA-MB-231 cells
Wnt/β-catenin signaling pathway has become a key signaling pathway regulating mammary organogenesis and oncogenesis. However, the therapeutic methods by targeting Wnt pathway against breast cancer has been limited. To address this challenge, we investigated the function of cyclin-dependent kinase 14...
ORGANISM(S): Homo sapiens 
2022-02-22 | GSE197000 | GEO
UnknownCDK14 regulates the development and repair of lung.
Not available
S-EPMC11743204 | biostudies-literature
UnknownGenetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
Not available
S-EPMC10994937 | biostudies-literature
UnknownDiscovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.
Not available
S-EPMC6588450 | biostudies-literature
UnknownmiR-216a inhibits osteosarcoma cell proliferation, invasion and metastasis by targeting CDK14.
Not available
S-EPMC5682665 | biostudies-literature
Unknown5-Hydroxytryptamine promotes non-small cell lung cancer metastasis via the SNRPG/WT1/CDK14 Axis.
Not available
S-EPMC12477100 | biostudies-literature
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