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MetabolomicsUntargeted metabolomics links glutathione to bacterial cell cycle progression
Cell cycle progression requires the coordination of cell growth, chromosome replication, and division. Consequently, a functional cell cycle must be coupled with metabolism. However, direct measurements of metabolome dynamics remained scarce, in particular in bacteria. Here, we describe an untargete...
2020-10-15 | MTBLS1402 | MetaboLights
MetabolomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response and chronic p38MAPK activation to promote long-term cell cycle arrest

Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibito...

2025-10-24 | MTBLS5868 | MetaboLights
MetabolomicsAmomum longiligulare polysaccharide 1 supplementation promotes the proliferation of jejunal epithelial cells in piglets by regulating the cell cycle and intestinal metabolites

Although nonstarch polysaccharides often have growth-promoting effects in animals, little is known about how polysaccharides act when administered as feed additives. Here, we demonstrate that Amomum longiligulare polysaccharide 1 (ALP1) improves the growth performanc...

2024-08-01 | MTBLS9835 | MetaboLights
MetabolomicsTCA cycle metabolomics of H3K27M Cell Nucleus Fraction and Cell Mitonchonrdial Fraction (Part-IV)
Not available
ORGANISM(S): Homo sapiens 
ST001026 | MetabolomicsWorkbench
MetabolomicsLuteal lipids regulate progesterone production and may modulate immune cell function during the estrous cycle and pregnancy
Not available
ORGANISM(S): Bos taurus 
ST001245 | MetabolomicsWorkbench
ProteomicsPhosphatase specificity influences the phosphorylation timing of CDK substrates during the cell cycle
Cell cycle events are ordered by cyclin-dependent kinases (CDKs), which phosphorylate hundreds of substrates. Multiple phosphatases oppose these CDK substrates, yet their collective role in regulating phosphorylation timing in vivo remains unclear. Here, we show that four phosphatases (PP2A-B55, PP2...
ORGANISM(S): Schizosaccharomyces pombe 927 
2025-10-05 | PXD060298 | Pride
Fission yeast Cdk Cell cycle Phosphatase 
ProteomicsLayers of regulation on cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae
In the budding yeast Saccharomyces cerevisiae, transcription factors (TFs) regulate the periodic expression of many genes during the cell cycle, including gene products required for progression through cell-cycle events. Experimental evidence coupled with quantitative models suggest that a network o...
ORGANISM(S): Saccharomyces Cerevisiae 
PXD010937 | panorama
ProteomicsEffect of glomerular disease on the podocyte cell cycle
Proteomic data from three populations of sorted murine podocytes using the FUCCI (fluorescence ubiquitination cell cycle indicator) Cell Cycle Sensor: Wild-Type podocytes at G0 (WT_G0), Alport Syndrome podocytes at G0 (AS_G0), and Alport Syndrome podocytes at G1 (AS_G1). Cell populations were sorted...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-01-15 | MSV000086705 | MassIVE
ProteomicsUncovering hidden layers of cell cycle regulation through integrative multi-omic analysis
Studying the complex relationship between transcription, translation and protein degradation is essential to our understanding of biological processes in health and disease. The limited correlations observed between mRNA and protein abundance suggest pervasive regulation of post-transcriptional step...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080771 | MassIVE
ProteomicsOrganising the cell cycle in the absence transcriptional control: Dynamic phosphorylation co-ordinates the Trypanosoma brucei cell cycle post-transcriptionally
The cell division cycle of the unicellular eukaryote Trypanosome brucei is tightly regulated despite the paucity of transcriptional control that results from the arrangement of genes in polycistronic units and lack of dynamically regulated transcription factors. To identify the contribution of dynam...
ORGANISM(S): Trypanosoma brucei 
2019-10-22 | PXD013488 | Pride
Trypanosoma brucei Phosphoproteomics Cell cycle Silac 
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