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ProteomicsStructural basis of the cyclin Y/14-3-3 protein-mediated activation of CDK16
Cyclin-dependent protein kinase 16 (CDK16) regulates both physiological and pathological processes, including autophagy, spermatogenesis and cancer. Unlike other CDKs, CDK16 is regulated by an unclear mechanism involving phosphorylated cyclin Y (CCNY) in complex with 14-3-3 proteins rather than CCNY...
ORGANISM(S): Escherichia coli 
2026-03-31 | PXD074528 | Pride
Structure Cdk16 Cyclin y/14-3-3 
ProteomicsAMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
The AMP-activated protein kinase (AMPK) is a master sensor of the cellular energy status and is crucial for the adaptive response to limited energy availability. AMPK is implicated in the regulation of many cellular processes, including autophagy. However, the precise mechanisms by which AMPK contro...
ORGANISM(S): Homo sapiens (Human) 
2020-02-17 | PXD009968 | Pride
Human Autophagy Nanolc-msms Phosphorylation 
ProteomicsStructural basis of the cyclin Y/14-3-3 protein-mediated activation of CDK16
Cyclin-dependent protein kinase 16 (CDK16) regulates both physiological and pathological processes, including autophagy, spermatogenesis and cancer. Unlike other CDKs, CDK16 is regulated by an unclear mechanism involving phosphorylated cyclin Y (CCNY) in complex with 14-3-3 proteins rather than CCNY...
ORGANISM(S): Homo sapiens (Human) 
2026-03-25 | PXD064389 | Pride
Cdk16 Cyclin-dependent protein kinase Ccny Cyclin y 14-3-3 protein 
GenomicsCDK16 is a vulnerable target for triple negative breast cancer therapy
CDK16 is a vulnerable target for triple negative breast cancer therapy
PRJNA784419 | ENA
ProteomicsStructural basis of the cyclin Y/14-3-3 protein-mediated activation of CDK16
Cyclin-dependent protein kinase 16 (CDK16) regulates both physiological and pathological processes, including autophagy, spermatogenesis and cancer. Unlike other CDKs, CDK16 is regulated by an unclear mechanism involving phosphorylated cyclin Y (CCNY) in complex with 14-3-3 proteins rather than CCNY...
ORGANISM(S): Homo sapiens (Human) 
2026-03-31 | PXD070539 | Pride
Hydrogen-deuterium exchange Cyclin y Cyclin-dependent protein kinase 16 14-3-3 proteins 
TranscriptomicsCDK16 is a vulnerable target for triple negative breast cancer therapy
Background: CDK16 is an atypical PCTAIRE kinase, and its activity is dependent on Cyclin Y (CCNY) family. CCNYs have been reported to regulate mammary stem cell activity and mammary gland development, and CCNY plays an oncogenic role in a variety of cancers including breast cancer. However, whether ...
ORGANISM(S): Homo sapiens 
2021-12-03 | GSE189758 | GEO
GenomicsCDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma [Huh7]
CDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma [Huh7]
PRJNA943193 | ENA
GenomicsUBA1-CDK16: A Female-Specific Chimeric RNA Emerging Through Evolution and Involved in Immune Regulation
UBA1-CDK16: A Female-Specific Chimeric RNA Emerging Through Evolution and Involved in Immune Regulation
PRJNA1368911 | ENA
UnknownStructure and inhibitor specificity of the PCTAIRE-family kinase CDK16.
Not available
S-EPMC5317395 | biostudies-literature
TranscriptomicsUBA1-CDK16: A Female-Specific Chimeric RNA Emerging Through Evolution and Involved in Immune Regulation
Chimeric RNAs resulting from intergenic splicing represent a novel mechanism for transcriptome expansion. To explore the role of this new layer of the transcriptome in sex-specific immunity, we analyzed RNA-seq data from 425 blood samples and identified the first female-specific chimeric RNA, UBA1-C...
ORGANISM(S): Homo sapiens 
2026-04-20 | GSE311311 | GEO
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