Sort   by:  
 Page size 
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [Colo205]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-67845 | biostudies-arrayexpress
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [LS-174-T]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-67846 | biostudies-arrayexpress
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [beta-catenin organoids]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Mus musculus 
2015-10-26 | E-GEOD-67847 | biostudies-arrayexpress
MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
TranscriptomicsRole of CDK8 in interferon-gamma-induced gene expression
Gene regulation by cytokine-activated STAT transcription factors requires serine phosphorylation within the transactivation domain (TAD). STAT1 and STAT3 TAD phosphorylation was reported to occur upon promoter binding by an unknown kinase. Here we show that the Mediator CDK8 module phosphorylates S7...
ORGANISM(S): Mus musculus 
2013-02-28 | E-GEOD-40728 | biostudies-arrayexpress
ProteomicsConfirmation of cdk8/19 inhibitor selectivity and activity in colorectal cancer
The Mediator complex is an evolutionarily conserved regulator of gene expression, influencing chromatin structure and RNA polymerase II-mediated transcription. Its activity is modulated by a protein kinase module, which includes cyclin-dependent kinases 8 and 19, that phosphorylate RNA polymerase II...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD061476 | Pride
Inhibitor Cdk19 Phosphoproteome Cdk8 Colorectal cancer 
TranscriptomicsCDK8 knockdown in HT-29 cells and CDK8 & MED12 knockdown in R1 cells
This SuperSeries is composed of the following subset Series: GSE30815: CDK8 knockdown in HT-29 human colon cancer cells GSE30816: CDK8 and MED12 knockdown in R1 mouse ES cells Refer to individual Series
ORGANISM(S): Mus musculus 
2012-03-05 | E-GEOD-30817 | biostudies-arrayexpress
ProteomicsIL6-regulated CDk8-mediated phosphoproteome of human primary Th1 cells
Cytokines are highly pleiotropic ligands that critically contribute to a balanced immune response. We have an incomplete understanding of how cytokines elicit their functional pleiotropy, which has limited their therapeutic efficacy. Here, using Interleukin-6 (IL-6) as a model system, we have perfor...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD020964 | Pride
Il6 Msc2530818 Human th1 cells Cdk8 inhibitor 
TranscriptomicsCDK8 knockdown in HT-29 human colon cancer cells
Transcriptional profiling of HT-29 human colon cancer cells transfected with non-targeting control (NTC) siRNA and two different siRNA sequences against CDK8 (siCDK8-1 and siCDK8-2). Three condition experiment comparing siNTC versus siCDK8-1 and siCDK8-2 after 3 days (3 biological replicates each); ...
ORGANISM(S): Homo sapiens 
2012-03-05 | E-GEOD-30815 | biostudies-arrayexpress
GenomicsConfirmation of CDK8/19 inhibitor selectivity and activity in colorectal cancer [in vitro]
Confirmation of CDK8/19 inhibitor selectivity and activity in colorectal cancer [in vitro]
PRJNA1225721 | ENA
Sort   by:  
 Page size