Sort   by:  
 Page size 
GenomicsRNA-seq analysis of PRCC-TFE3 dependent transcriptional programs and their modulation by MSC2530818 in HK-2 cells.
RNA-seq analysis of PRCC-TFE3 dependent transcriptional programs and their modulation by MSC2530818 in HK-2 cells.
PRJNA1404254 | ENA
UnknownSystemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition.
Not available
S-EPMC6912361 | biostudies-literature
TranscriptomicsRNA-seq analysis of PRCC-TFE3 dependent transcriptional programs and their modulation by MSC2530818 in HK-2 cells.
PRCC-TFE3 is an oncogenic chimeric transcription factor identified in TFE3-rearranged renal cell carcinoma. To characterize PRCC-TFE3–dependent transcriptional programs and their regulation by the Mediator kinase module, we performed RNA sequencing in a doxycycline-inducible PRCC-TFE3 expression sys...
ORGANISM(S): Homo sapiens 
2026-03-18 | GSE316808 | GEO
UnknownDevelopment of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19.
Not available
S-EPMC8591729 | biostudies-literature
ProteomicsIL6-regulated CDk8-mediated phosphoproteome of human primary Th1 cells
Cytokines are highly pleiotropic ligands that critically contribute to a balanced immune response. We have an incomplete understanding of how cytokines elicit their functional pleiotropy, which has limited their therapeutic efficacy. Here, using Interleukin-6 (IL-6) as a model system, we have perfor...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD020964 | Pride
Il6 Msc2530818 Human th1 cells Cdk8 inhibitor 
TranscriptomicsTranscriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems [RNA-seq]
Fibroblasts can be chemically induced to pluripotent stem cells (CiPSCs) through an extraembryonic endoderm (XEN)-like state or directly converted into other differentiated cell lineages. However, the mechanisms underlying chemically-induced cell fate reprogramming remain unclear. Here, a transcript...
ORGANISM(S): Mus musculus 
2023-05-19 | GSE227569 | GEO
TranscriptomicsTranscriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems [Drug-seq2]
Fibroblasts can be chemically induced to pluripotent stem cells (CiPSCs) through an extraembryonic endoderm (XEN)-like state or directly converted into other differentiated cell lineages. However, the mechanisms underlying chemically-induced cell fate reprogramming remain unclear. Here, a transcript...
ORGANISM(S): Mus musculus 
2023-05-19 | GSE227568 | GEO
GenomicsTranscriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems [ATAC-seq]
Fibroblasts can be chemically induced to pluripotent stem cells (CiPSCs) through an extraembryonic endoderm (XEN)-like state or directly converted into other differentiated cell lineages. However, the mechanisms underlying chemically-induced cell fate reprogramming remain unclear. Here, a transcript...
ORGANISM(S): Mus musculus 
2023-05-19 | GSE227566 | GEO
GenomicsTranscriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems [RNA-seq]
Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems [RNA-seq]
PRJNA945840 | ENA
GenomicsTranscriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems [ATAC-seq]
Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems [ATAC-seq]
PRJNA945838 | ENA
Sort   by:  
 Page size