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MetabolomicsFFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights
ProteomicsN-Glycosylation-Defective IL6 Alternatively Activates the SRC-YAP-SOX2 Axis to Drive Metastasis and EGFR TKI Resistance
The IL6-GP130-STAT3 pathway facilitates lung cancer progression and resistance to tyrosine kinase inhibitors. Although glycosylation alters the stability of GP130, its effect on the ligand IL6 remains unclear. We herein found that N-glycosylated IL6, especially at Asn73, primarily stimulates JAK-STA...
ORGANISM(S): Homo sapiens (Human) 
2025-01-18 | PXD051771 | Pride
Il6  glycosylation  lung cancer  emt  metastasis  egfr-tki resistance  src  yap 
TranscriptomicsIL6-STAT3 downstream targets in MCF10A/MCF10A.ErbB2* cells
Overexpression in IL6 in MCF10A vs. WT, MCF10A.ErbB2* with/without shRNA targeting STAT3 Overexpression in IL6 in MCF10A vs. WT, MCF10A.ErbB* with/without shSTAT3, duplicates, two STAT3 shRNAs
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-62235 | biostudies-arrayexpress
GenomicsMDMs Solvent, AA, IL6, AA+IL6
MDMs Solvent, AA, IL6, AA+IL6
PRJEB36942 | ENA
ProteomicsIL6/STAT3 co-opts ER regulatory elements to drive metastasis in breast cancer
Interleukin 6 (IL6) signaling has been associated with an aggressive and metastatic phenotype in multiple solid tumors including breast cancer, but its mechanism of action in mediating tumor progression and treatment response is not clear. By exploiting a clinically relevant intraductal xenograft mo...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012980 | Pride
Cancer Il6 Stat3 Metastasis 
ModelsSoni2018 - IL6 induced M2 Phenotype in Leishmania major infected macrophage
IL-6 has been proposed to favor the development of Th2 responses and play an important role in the communication between cells of multicellular organisms. They are involved in the regulation of complex cellular processes such as proliferation, differentiation and act as key player during inflammatio...
2024-09-02 | BIOMD0000000873 | BioModels
GenomicsHuman monocyte stimulation with IL6
Human monocyte stimulation with IL6
PRJNA979179 | ENA
ProteomicsShort Term Immune Response to IL6 inhibition (Tocilizumab)
we examined the effects of IL6 inhibition treatment on biologic molecular pathways in a 59 year old patient well diagnosed with RA with inadequate response to DMARD thus treated with tocilizumab. To assess the immunological outcome we used quantitative proteome analysis to evaluate changes in the pr...
ORGANISM(S): Homo sapiens (Human) 
2016-01-05 | PXD002686 | Pride
Tocilizumab Il6 Rheumatoid arthritis 
ProteomicsKupffer cell-derived IL6 promotes hepatocellular carcinoma metastasis via the JAK1-ACAP4 pathway
Tumor-associated macrophages (TAMs), which differentiate from tissue-resident macrophages, are recognized for their ability to influence cancer progression and metastasis. However, the specific role of Kupffer cells, the intrinsic macrophages of the liver, in the progression of hepatocellular carcin...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD057481 | Pride
Mhcc97h，thle-2 
TranscriptomicsCrosstalk between very different family members: How STAT3 activating IL6-type cytokines inhibit the IFNg-like responses of IL27 in hepatocellular carcinoma cells
Interleukin-27 (IL27) is a type-I-cytokine of the IL6/IL12 family predominantly secreted by activated macrophages and dendritic cells. Best understood are the effects of IL27 on immune cells where it has been described to have pro- or anti-inflammatory properties, either promoting TH1 responses or s...
ORGANISM(S): Homo sapiens 
2017-07-05 | E-MTAB-4570 | biostudies-arrayexpress
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