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rs10-06_cdka - cdka mutants - difference in global transcript in mutants with an affected cell cycle progression - compare wild type plants with mutant plants that show a reduced activity of CDKA1, the key cell cycle regulator in Arabidopsis thaliana 6 dye-swap - wt vs mutant comparison
ORGANISM(S): Arabidopsis thaliana 
rs10-06_cdka - cdka mutants - difference in global transcript in mutants with an affected cell cycle progression - compare wild type plants with mutant plants that show a reduced activity of CDKA1, the key cell cycle regulator in Arabidopsis thaliana
ORGANISM(S): Arabidopsis thaliana 
2012-03-20 | GSE36275 | GEO
Two genes have a synthetic lethal relationship when silencing or inhibition of one gene is only lethal in the context of a mutation or activation of the second gene. This situation offers an attractive therapeutic strategy, as inhibition of such a gene will only trigger cell death in tumor cells wit...
ORGANISM(S): Homo sapiens 
Cyclin E1 (CCNE1) is amplified in various tumor types including high-grade serous ovarian cancer where it is associated with poor clinical outcome. We have demonstrate that suppression of the Cyclin E1 partner kinase, CDK2, induces apoptosis in a CCNE1 amplicon-dependent manner. Little is known of m...
ORGANISM(S): Homo sapiens 
cdka mutants-cdka mutants
Cyclin E1 (CCNE1) is amplified in various tumor types including high-grade serous ovarian cancer where it is associated with poor clinical outcome. We have demonstrate that suppression of the Cyclin E1 partner kinase, CDK2, induces apoptosis in a CCNE1 amplicon-dependent manner. Little is known of m...
ORGANISM(S): Homo sapiens 
Meiosis is a complex cell division program reducing chromosome number as a prerequisite for sexual reproduction and at the same time leading to a new combination of parental alleles contributing to biodiversity. Little is known about how the distinct order of the molecular processes of meiosis are o...
ORGANISM(S): Arabidopsis Thaliana 
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