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ProteomicsCDKL1 risk variants predispose to a connective tissue disorder with thoracic aortic aneurysm and dissection
Genetic factors are fundamental in the etiology of thoracic aortic aneurysm and dissection (TAAD), but the genetic cause is detected in only about 30% of cases. To define unreported TAAD-associated sequence variants, exome and gene panel sequencing was performed in 323 patients. We identified hetero...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD048044 | Pride
Cdkl1 Cgmp signaling Thoracic aortic aneurysm and dissection Arterial aneurysm and dissection Hereditary aortopathy Connective tissue disorder 
TranscriptomicsExpression data from colorectal cancer cell lines transfected with CDKL1-shRNA
CDKL1 protein was overexpressed in colorectal cancer tissues compared with paired normal tissue. Knockdown of CDKL1 in HCT116 and Caco2 significantly inhibited cell growth, colony formation ability, tumor invasion, and G1-S phase transition of the cell cycle. We used microarrays to detail the gene e...
ORGANISM(S): Homo sapiens 
2017-02-15 | GSE94887 | GEO
UnknownCDKL1 promotes tumor proliferation and invasion in colorectal cancer.
Not available
S-EPMC5360398 | biostudies-literature
UnknownDownregulation of CDKL1 suppresses neuroblastoma cell proliferation, migration and invasion.
Not available
S-EPMC6407201 | biostudies-literature
UnknownCDKL1 variants affecting ciliary formation predispose to thoracic aortic aneurysm and dissection.
Not available
S-EPMC12646653 | biostudies-literature
UnknownDe novo variants in CDKL1 and CDKL2 are associated with neurodevelopmental symptoms.
Not available
S-EPMC12081231 | biostudies-literature
UnknownCDKL1 potentiates the antitumor efficacy of radioimmunotherapy by binding to transcription factor YBX1 and blocking PD-L1 expression in lung cancer.
Not available
S-EPMC10958935 | biostudies-literature
GenomicsHomo sapiens
Expression data from colorectal cancer cell lines transfected with CDKL1-shRNA
PRJNA374725 | ENA
UnknownCDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
Not available
S-EPMC5846859 | biostudies-literature
UnknownEvaluation of Type 2 Diabetes Risk Variants (Alleles) in the Pashtun Ethnic Population of Pakistan.
Not available
S-EPMC10207872 | biostudies-literature
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