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ProteomicsSynthetic polyclonal-derived CDR peptides as innovative strategy in glaucoma therapy
The pathogenesis of glaucoma is strongly associated with the occurrence of autoimmune-mediated loss of retinal ganglion cells (RGCs) and recently it was proven that specific antibody-derived signature peptides are significantly differentially expressed in sera of primary open angle glaucoma patients...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2019-08-15 | PXD014718 | Pride
Glaucoma  autoimmunity  synthetic cdr peptides  neuroprotection  htra2  sus scrofa domesticus 
GenomicsCereibacter johrii strain:CDR-SL 7Cii
Cereibacter johrii strain:CDR-SL 7Cii Genome sequencing and assembly
PRJNA453914 | ENA
TranscriptomicsGene expression data for mock and 5-Aza-CdR treated colorectal cancer (CRC) cell lines SW480, HCT116 and RKO
DNA hypermethylated genes undergo silencing and show re-expression in response to 5-Aza-CdR treatment. Agilent arrays were used to determine the genes that get reactivated in response to the drug treatment. To determine expression levels of genes in SW480, HCT116 and RKO.
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-50510 | biostudies-arrayexpress
GenomicsThe differentially expressed genes regulated by 5-Aza-CdR
The differentially expressed genes regulated by 5-Aza-CdR
PRJNA889369 | ENA
GenomicsGenome-wide maps of RNAPII Ser5(P) in HEK 293T cells after treatment with 5-aza-CdR
DNA methylation can be abnormally regulated in human disease and associated with effects on gene transcription that appear to be causally related to pathogenesis. The potential to use pharmacological agents that reverse this dysregulation is therefore an attractive possibility. To test how 5-aza-2...
ORGANISM(S): Homo sapiens 
2015-02-13 | E-GEOD-62695 | biostudies-arrayexpress
TranscriptomicsmRNA profile of 5-aza-CR and 5-aza-CdR treated celllines
5-azacytidine and 5-aza-2'-deoxycytidine are both demethylating agents but they have shown different clinical efficiency. Since 5-azacytidine is incorporated into RNA it might have a different impact on the expression profile than 5-aza-2'-deoxycytidine. This study is designed to investigate the imm...
ORGANISM(S): Homo sapiens 
2014-06-13 | E-MTAB-280 | biostudies-arrayexpress
ProteomicsRegulation of the HTRA2 protease activity by PDZ domain-binding peptide ligands and the influence on HTRA2-specific protein interaction networks in retinal tissues
For the identification of HTRA2-specific protein interaction partners in retinal tissues of the house swine (Sus scrofa), we performed co-immunoprecipitation experiments with recombinant 6His-tag HTRA2 followed by quantitative LC-MS-based proteomics (see Fig. 2A and File S1). In brief, 2 µg recombin...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2021-10-11 | PXD024442 | Pride
Htra2  neuroprotection  retina  interaction partners  co-immunoprecipitation  mass spectrometry 
ProteomicsComplementarity Determining Regions in SARS-CoV-2 hybrid immunity
Pre-vaccination SARS-CoV-2 infection can boost protection elicited by COVID-19 vaccination and post-vaccination breakthrough SARS-CoV-2 infection can boost existing immunity conferred by COVID-19 vaccination. Such ‘hybrid immunity’ is effective against SARS-CoV-2 variants. In order to understand ‘hy...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD038849 | Pride
Human Cdr Covid 19 
GenomicsThe differentially expressed genes after treatment of 5-AZA-CdR in OSCC cell lines
The differentially expressed genes after treatment of 5-AZA-CdR in OSCC cell lines
PRJNA1333310 | ENA
TranscriptomicsThe differentially expressed genes regulated by 5-Aza-CdR
This study aimed to identify the differentially expressed genes regulated by 5-Aza-CdR
ORGANISM(S): Homo sapiens 
2023-02-23 | GSE215214 | GEO
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