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MetabolomicsMulti-omics uncovers formononetin's protection against antibiotic-induced liver injury via microbiota-metabolite-transcriptome coordination

Tetracycline antibiotics (TETs) cause hepatotoxicity via gut-liver axis disruption and oxidative stress. This study evaluated whether formononetin (FMN), a natural isoflavone, alleviates TET-induced liver injury through microbiota-metabolite-transcriptome coordination. Using network toxicology an...

2025-10-17 | MTBLS13161 | MetaboLights
MetabolomicsMulti-omics uncovers formononetin's protection against antibiotic-induced liver injury via microbiota-metabolite-transcriptome coordination

Tetracycline antibiotics (TETs) cause hepatotoxicity via gut-liver axis disruption and oxidative stress. This study evaluated whether formononetin (FMN), a natural isoflavone, alleviates TET-induced liver injury through microbiota-metabolite-transcriptome coordination. Using network toxicology an...

2025-10-14 | MTBLS13138 | MetaboLights
MetabolomicsIntegrated pharmacological and metabolomic characterization of a polysaccharide-enriched fraction from Qingfei-Paidu Decoction for protection against acute lung injury in mice
The formula of Qingfei-Paidu Decoction was separated into a polysaccharide-enriched fraction (PSC) and an ethanol-soluble small-molecule fraction (EtOH), whose biological activities were systematically compared under equivalent crude drug conditions using an LPS-induced ALI mouse model and macrophag...
2026-10-05 | MTBLS15898 | MetaboLights
MetabolomicsSS-31-Loaded Panax notoginseng-Derived Nanovesicles Embedded in a Composite Hydrogel for Multilevel Protection Against Blue-Light-Induced Corneal Injury
Prolonged blue-light (BL) exposure from digital devices induces oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis in human corneal epithelial cells (HCECs), yet effective multilevel protective strategies remain limited. Here, we developed a hierarchically assembled composite o...
2026-10-23 | MTBLS16102 | MetaboLights
MetabolomicsProphylactic and therapeutic itaconate treatment alleviates COVID-19-associated lung injury

Although itaconate demonstrates anti-inflammatory and antimicrobial properties as an immunomodulatory metabolite, the therapeutic potential and mechanistic basis of vaccine-induced or prophylactic itaconate administration in COVID-19 intervention remains underexplored. Our studies reveal that int...

2025-08-06 | MTBLS12827 | MetaboLights
MetabolomicsPentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Using a genetically encoded fluorescent indicator, we found that ex...

2026-03-22 | MTBLS14090 | MetaboLights
MetabolomicsMechanism of Organic Plant Protection Technology in Controlling Apple Bitter Pit: Insights from Integrated Transcriptomic and Metabolomic Analyses

Apple bitter pit (ABP), a severe physiological disorder, severely impairs the quality and yield of the susceptible 'Qingcui' apple. This study investigated the control efficacy and mechanism of a three-in-one Organic Plant Protection Technology (OPPT) against ABP, with treatments set as control (...

2026-02-26 | MTBLS13937 | MetaboLights
MetabolomicsPentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Using a genetically encoded fluorescent indicator, we found that ex...

2026-04-13 | MTBLS14264 | MetaboLights
MetabolomicsMicrobiome-produced nicotinic acid controls colon regional identity and injury susceptibility

Regional structure of the intestinal epithelium is critical for its function and is associated with the risk of specific gut diseases. However, how regionalization is established and how it influences disease susceptibility remains poorly understood. Here, we investigated the role of the gut micr...

2026-03-27 | MTBLS12063 | MetaboLights
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
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