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MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
MetabolomicsInulin gel-mediated delivery of Clostridium butyricum spores protects against acute kidney injury via regulation of ER-mitochondria contacts
Acute kidney injury (AKI) progression is closely associated with gut microbiota dysbiosis. However, the detailed mechanism remains unclear. In this study, we found that patients with AKI had decreased beneficial bacteria and reduced butyric acid levels in the intestine. Furthermore, butyrate allevia...
2026-09-17 | MTBLS15607 | MetaboLights
UnknownDynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation.
Not available
S-EPMC8577825 | biostudies-literature
TranscriptomicsIdentifying multi-locus chromatin contacts in human cells using tethered multiple 3C
Background: DNA in the nucleus of a living cell carries out its functions in the context of a complex, three-dimensional chromatin architecture. Several recently developed methods, each an extension of the chromatin conformation capture (3C) assay, have enabled the genome-wide profiling of chroma...
ORGANISM(S): Homo sapiens 
2015-04-29 | E-GEOD-60623 | biostudies-arrayexpress
UnknownPTK7-Src signaling at epithelial cell contacts mediates spatial organization of actomyosin and planar cell polarity.
Not available
S-EPMC4086913 | biostudies-literature
ProteomicsCell rearrangement during angiogenesis requires suppression of actomyosin at cell-cell contacts via PI3-kinase.
Sprouting angiogenesis is a highly dynamic process which relies on the continuous interchange of endothelial cell relative position within the vascular sprout, a process mediated by cell rearrangements. Here we take advantage of a previous identified role of p110a/PI3K regulating endothelial cell mo...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-02 | PXD007060 | Pride
Mascot Pescal Phosphoproteomics Qexactive-plus Mice 
TranscriptomicsBlood Transcriptional Profiling of a prospective HIV-negative UK Cohort of Tuberculosis Contacts
Blood transcriptional signatures may predate clinical diagnosis and detect subclinical incipient tuberculosis (TB) disease. To validate such blood signatures, close contacts of TB patients were recruited from multiple TB clinics in London. Close contacts of active TB were defined as individuals with...
ORGANISM(S): Homo sapiens 
2019-08-29 | E-MTAB-6845 | biostudies-arrayexpress
UnknownHAb18G/CD147 cell-cell contacts confer resistance of a HEK293 subpopulation to anoikis in an E-cadherin-dependent manner.
Not available
S-EPMC2864199 | biostudies-literature
UnknownCollective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.
Not available
S-EPMC3018349 | biostudies-literature
UnknownMyosin VI and vinculin cooperate during the morphogenesis of cadherin cell cell contacts in mammalian epithelial cells.
Not available
S-EPMC2064848 | biostudies-literature
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